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Microglia

Physiology, Pathophysiology and Therapeutic Potential

  • Book
  • © 2024

Overview

Editors:
  1. Marie-Ève Tremblay

    1. Division of Medical Sciences, University of Victoria, Victoria, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Alexei Verkhratsky

    1. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

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    You can also search for this editor in PubMed   Google Scholar

  • Covers the role of microglia in the healthy brain as well as in pathological conditions
  • Presents the first comprehensive coverage of this hot topic
  • Features contributions from the major names in the field across 5 continents

Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 37)

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About this book

The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucial involvement with diseases.  Edited by Drs. Marie-Ève Tremblay and Alexei Verkhratsky, Microglia: Physiology, Pathophysiology and Therapeutic Potential shares with the scientific and medical community the latest discoveries in the microglial research field, with a truly comprehensive collection of  chapters written by the top specialists across five continents. The book begins by explaining briefly what they are, from both historical and evolutionary points of view, and how they can be studied. The first section explains their physiological roles in the maturation, function, and plasticity of the CNS. The second section focuses on their general involvement in neuropathophysiology, and the third section on their critical implication in specific CNS diseases, including neurotrauma, neuropathic pain, ischemia and stroke, infectious diseases, autoimmune diseases, neurodevelopmental and neuropsychiatric disorders, substance use and addiction, sleep disorders, ageing, and neurodegenerative diseases. The fourth section presents their clinical potential as a targeted therapeutic tool for these  CNS diseases.


Keywords

Table of contents (35 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. General Pathophysiology of Microglia

      • Marie-Ève Tremblay, Alexei Verkhratsky
      Pages 3-14

    3. History of Microglia

      • Payam Rezaie, Uwe-Karsten Hanisch
      Pages 15-37

    4. Evolution of Microglia

      • Elena Guffart, Marco Prinz
      Pages 39-51

    5. Visualization, Fate Mapping, Ablation, and Mutagenesis of Microglia in the Mouse Brain

      • Jung-Seok Kim, Steffen Jung
      Pages 53-63

    6. Progress in Structural and Functional In Vivo Imaging of Microglia and Their Application in Health and Disease

      • Alexis Crockett, Martin Fuhrmann, Olga Garaschuk, Dimitrios Davalos
      Pages 65-80

  3. Basic Discoveries in Physiology

    1. Front Matter

      Pages 81-81
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    2. Receptors on Microglia

      • Marcus Augusto-Oliveira, Marie-Ève Tremblay, Alexei Verkhratsky
      Pages 83-121

    3. Calcium Signalling in Microglia

      • Olga Garaschuk, Alexei Verkhratsky
      Pages 123-133

    4. Contactomics of Microglia and Intercellular Communication

      • Csaba Cserép, Balázs Pósfai, Eszter Szabadits, Ádám Dénes
      Pages 135-149

    5. Microglial Phagocytosis During Embryonic and Postnatal Development

      • José L. Marín-Teva, M. Rosario Sepúlveda, Veronika E. Neubrand, Miguel A. Cuadros
      Pages 151-161

    6. Microglia Colonization Associated with Angiogenesis and Neural Cell Development

      • G. Jean Harry
      Pages 163-178

    7. Synapse Regulation

      • Haley A. Vecchiarelli, Luana Tenorio Lopes, Rosa C. Paolicelli, Beth Stevens, Hiroaki Wake, Marie-Ève Tremblay
      Pages 179-208

    8. Microglial Modulation of Synaptic Maturation, Activity, and Plasticity

      • Maria Joana Pinto, Davide Ragozzino, Alain Bessis, Etienne Audinat
      Pages 209-219

    9. Adult Neurogenesis, Learning and Memory

      • Eva Šimončičová, Keelin Henderson Pekarik, Haley A. Vecchiarelli, Clotilde Lauro, Laura Maggi, Marie-Ève Tremblay
      Pages 221-242

    10. Microglial Regulation of Sleep and Wakefulness

      • Linh Le, Kazuya Miyanishi, Junya Tanaka, Ania K. Majewska
      Pages 243-260

  4. General Pathophysiology of Microglia

    1. Front Matter

      Pages 261-261
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    2. Roles in Innate Immunity

      • Kaira A. Church, Astrid E. Cardona, Sarah C. Hopp
      Pages 263-286

    3. Microglia and Systemic Immunity

      • Paloma Marinho Jucá, Érica de Almeida Duque, Luiza Helena Halas Covre, Kairo Alan Albernaz Mariano, Carolina Demarchi Munhoz
      Pages 287-302
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Editors and Affiliations

  • Division of Medical Sciences, University of Victoria, Victoria, Canada

    Marie-Ève Tremblay

  • Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

    Alexei Verkhratsky

About the editors

Marie-Eve Tremblay , Ph.D. is a Canada Research Chair (Tier II) in Neurobiology of Aging and Cognition, and an Associate Professor in the Division of Medical Sciences at the University of Victoria in Victoria, Canada. Her research findings have stimulated the development of a totally new field of research investigating the roles of microglia in the healthy brain. 

Alexei Verkhratsky, MD, Ph.D., DSc. is Professor of Neurophysiology in the Faculty of Biology, Medicine and Health at The University of Manchester in Manchester, England. Alexei Verkhratsky is an internationally recognized scholar in the field of cellular neurophysiology, best known for his contributions to our knowledge of the physiology and pathophysiology of neuroglia.

Bibliographic Information

  • Book Title: Microglia

  • Book Subtitle: Physiology, Pathophysiology and Therapeutic Potential

  • Editors: Marie-Ève Tremblay, Alexei Verkhratsky

  • Series Title: Advances in Neurobiology

  • DOI: https://doi.org/10.1007/978-3-031-55529-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2024

  • Hardcover ISBN: 978-3-031-55528-2Published: 30 August 2024

  • Softcover ISBN: 978-3-031-55531-2Due: 13 September 2025

  • eBook ISBN: 978-3-031-55529-9Published: 29 August 2024

  • Series ISSN: 2190-5215

  • Series E-ISSN: 2190-5223

  • Edition Number: 1

  • Number of Pages: XIII, 644

  • Number of Illustrations: 3 b/w illustrations, 72 illustrations in colour

  • Topics: Neurosciences, Neurology, Immunology

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