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Physical Virology

Virus Structure and Mechanics

  • Book
  • © 2019

Overview

Editors:
  1. Urs F. Greber

    1. Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

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  • Assists readers to understand the physical nature of virus particles and their impact on disease mechanisms, precision medicine, and controlled drug delivery
  • Brings together an interdisciplinary group of mathematicians, physicists, chemists, and biologists to explore the physical nature of virus particles
  • Explores how virus particles interact with cells during entry and assembly, and link the cell biology of the underlying processes with the physical nature of the particles

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1215)

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About this book

This book explores a new challenge in virology: to understand how physical properties of virus particles (virions) and viruses (infected cells) affect the course of an infection. Insights from the emerging field of physical virology will contribute to understanding of the physical nature of viruses and cells, and will open new ways for anti-viral interference.

Nine chapters and an editorial written by physicists, chemists, biologists and computational experts describe how virions serve as trail blazers in uncharted territory of cells. The authors outline how particles change in composition as they interact with host cells. Such virus dynamics are crucial for virus entry into cells and infection. It influences the modern concepts of virus-host interactions, viral lineages and evolution.

The volume gives numerous up-to-date examples of modern virology and provides a fascinating read for researchers, clinicians and students in the field of infectious diseases.

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Editorial: Physical Virology and the Nature of Virus Infections

    • Urs F. Greber
    Pages 1-11

  3. Single Virion Tracking Microscopy for the Study of Virus Entry Processes in Live Cells and Biomimetic Platforms

    • Lakshmi Nathan, Susan Daniel
    Pages 13-43

  4. Structural Insights into Rotavirus Entry

    • Javier M. Rodríguez, Daniel Luque
    Pages 45-68

  5. The HIV-1 Capsid: More than Just a Delivery Package

    • Leo C. James
    Pages 69-83

  6. Membrane-Containing Icosahedral Bacteriophage PRD1: The Dawn of Viral Lineages

    • Hanna M. Oksanen, Nicola G. A. Abrescia
    Pages 85-109

  7. Structure and Function of Negri Bodies

    • Jovan Nikolic, Cécile Lagaudrière-Gesbert, Nathalie Scrima, Danielle Blondel, Yves Gaudin
    Pages 111-127

  8. Virus Maturation

    • Carmen San Martín
    Pages 129-158

  9. Atomic Force Microscopy of Viruses

    • P. J. de Pablo, I. A. T. Schaap
    Pages 159-179

  10. Alkalinization of Icosahedral Non-enveloped Viral Capsid Interior Through Proton Channeling

    • Maria Marta Branda, Diego M. A. Guérin
    Pages 181-199

  11. Computational Virology: Molecular Simulations of Virus Dynamics and Interactions

    • Elizabeth E. Jefferys, Mark S. P. Sansom
    Pages 201-233

  12. Correction to: Physical Virology

    • Urs F. Greber
    Pages C1-C1
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Editors and Affiliations

  • Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

    Urs F. Greber

Bibliographic Information

  • Book Title: Physical Virology

  • Book Subtitle: Virus Structure and Mechanics

  • Editors: Urs F. Greber

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-030-14741-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-14740-2Published: 30 July 2019

  • Softcover ISBN: 978-3-030-14743-3Published: 14 August 2020

  • eBook ISBN: 978-3-030-14741-9Published: 17 July 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 235

  • Number of Illustrations: 4 b/w illustrations, 52 illustrations in colour

  • Topics: Medical Microbiology, Virology, Infectious Diseases

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