Overview
- Reviews the current status of the field of lipid signaling focused on translational significance with the prospect to be clinically relevant for human disease
- The book combines both basic principles and applied agents with clinical significance for lipid cell signaling, phospholipases and lipid kinases, lipid metabolism and trafficking, and bioactive lipids
- Drug development and novel application ideas are incorporated where possible
Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 259)
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About this book
Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease.
Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important.
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Keywords
Table of contents (14 chapters)
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Front Matter
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New Roles for Sphingolipid Signaling and Cell Function
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Front Matter
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Phospholipase D and Mitogen Phosphatidic Acid in Human Disease
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Front Matter
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Lipid Kinases and Novel Regulatory Pathways
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Front Matter
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Bioactive Lipids in Health and Disease
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Front Matter
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Lipids and Membrane Microdomains
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Front Matter
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Nuclear Trafficking of Lipids
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Front Matter
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Editors and Affiliations
Bibliographic Information
Book Title: Lipid Signaling in Human Diseases
Editors: Julian Gomez-Cambronero, Michael A. Frohman
Series Title: Handbook of Experimental Pharmacology
DOI: https://doi.org/10.1007/978-3-030-33668-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2020
Hardcover ISBN: 978-3-030-33667-7Published: 25 April 2020
Softcover ISBN: 978-3-030-33670-7Published: 25 April 2021
eBook ISBN: 978-3-030-33668-4Published: 24 April 2020
Series ISSN: 0171-2004
Series E-ISSN: 1865-0325
Edition Number: 1
Number of Pages: XIV, 336
Number of Illustrations: 20 b/w illustrations, 30 illustrations in colour
Topics: Pharmacology/Toxicology, Cancer Research, Medical Biochemistry