Circulating Tumor Cells, From Biotech Innovation to Clinical Utility Part A

Erscheinungsjahr 2023
ISBN: 978-0-443-16134-6
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 151 mm x 229 mm, Gewicht: 450 g

"Circulating Tumor Cells, from biotech innovation to clinical utility" provides an overview of the most recent technological and clinical advances with regards to the study of circulating tumor cells (CTCs) in solid tumors. The volumes cover studies on CTCs in breast, prostate, colorectal and lung cancer, with a focus on clinical utility, and also include methodological and biological topics such as CTC culture, multi-omic characterization of CTCs, atypical CTC populations and interaction between CTCs and immunity.

Autoren/Hrsg.

Weitere Mitwirkende

Reduzzi, Carolina

Gerratana, Lorenzo

Fachgebiete

• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

1. Latest advances in clinical studies of circulating tumor cells in early and metastatic breast cancer Laura S. Munoz-Arcos, Eleonora Nicolò, Mara S. Serafini, Lorenzo Gerratana, Carolina Reduzzi, and Massimo Cristofanilli 2. Can we define breast cancer HER2 status of by liquid biopsy? Serena Di Cosimo, Cinzia De Marco, Marco Silvestri, Adele Busico, Andrea Vingiani, Giancarlo Pruneri, and Vera Cappelletti 3. Models to study CTCs and CTC culture methods Cristóbal Fernández-Santiago, Rafael López-López, and Roberto Piñeiro Cid 4. Settling the uncertainty about unconventional circulating tumor cells: epithelial-to-mesenchymal transition, cell fusion and trogocytosis Giulia Gallerani, Tania Rossi, Manuela Ferracin, and Massimiliano Bonafè 5. Circulating tumor cells in cancer-risk populations as a cancer interception tool María José Serrano, Christian Rolfo, José Expósito-Hernandez, Carmen Garrido-Navas, José Javier Lopez-Hidalgo, and Valeria Denninghoff 6. Circulating tumor cells and host immunity: a tricky liaison Elena Muraro and Giulia Brisotto

Über Autor(innen)

Gerratana, Lorenzo
Lorenzo Gerratana is a Physician scientist at the IRCCS CRO Aviano National cancer Institute and a Research fellow at the Department of Medicine at the University of Udine. After graduating as MD, he focused on DNA repair in vitro models in Triple Negative Breast Cancer, clinical methodology and endpoint analysis. As a medical oncology fellow at the University of Udine and visiting scholar at the Northwestern University of Chicago he focused his research on liquid biopsy and big data, with the aim of transferring promising tissue and liquid biopsy-based biomarkers and treatment strategies from the bench to the bedside, with a pragmatic imprinting towards clinical utility and transferability. He currently serves as Attending Physician at the IRCCS CRO Aviano National Cancer Institute as part of the Breast Unit and the Precision Medicine Multidisciplinary Team.

Reduzzi, Carolina
Carolina Reduzzi is a Research Associate at Weill Cornell Medicine. She obtained a degree with laude in Biology Applied to Biomedical Research in 2014 at the University of Milan. She has been working on liquid biopsy for the last decade, first at the National Cancer Institute of Milan (Fondazione IRCCS Istituto Nazionale dei Tumori), where she obtained her PhD in 2020, and subsequently at the Northwestern University of Chicago, where she conducted her postdoctoral research on circulating tumor cells in breast cancer. Since 2022 she is the Director of Dr. Cristofanilli's laboratory at Weill Cornell Medicine. She is a member of the Young Committee of the International Society of Liquid Biopsy, reviewer for different journals including Cell Reports, Scientific Reports, Cancers and BMC Cancer, and grant reviewer for the Italian Health Ministry and the Fondation Toulouse Cancer Santé.