Roboz Mass Spectrometry in Cancer Research

Erscheinungsjahr 2002
ISBN: 978-1-4200-4269-6
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 576 Seiten

Cancer research is becoming multidisciplinary. The complex structural and therapeutic problems require synergistic approaches employing an assortment of biochemical manipulations, chromatographic or electrophoretic separations, sequencing strategies, and … more and more mass spectrometry.

Mass Spectrometry in Cancer Research provides a broad examination of current strategies and techniques and their application to the study of:

(i) occupational and environmental carcinogens;

(ii) antineoplastic and chemopreventive agents;

(iii) pertinent proteins, lipids, nucleic acids and glycoconjugates. Also included are a chapter on instrumentation and methodologies for biologists and physicians and a brief review of the relevant concepts of cancer biology and medicine for mass spectrometrists.

This book is intended for: mass spectrometrists in research or those providing core services; researchers in biological, medical, pharmaceutical or environmental sciences; physicians in academic medicine; and academic/industrial research managers.

Zielgruppe

Mass spectrometrists in research or those providing core services; researchers in biological, medical, pharmaceutical or environmental sciences; physicians in academic medicine; and academic/industrial research managers

Autoren/Hrsg.

Roboz, John

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Chemie Analytische Chemie Massenspektrometrie, Spektroskopie, Spektrochemie

Inhaltsverzeichnis

OVERVIEW AND SCOPE OF APPLICATIONS
The Essentials
Functions and Types of Instrument Components
Measures of Performance
Information from Mass Spectra and Scope of Applications
INSTRUMENTATION AND TECHNIQUES OF MASS SPECTROMETRY
Ion Sources
Mass Analyzers
Ion Current Detectors
Mass Spectrometry-Mass Spectrometry (MS/MS)
Identification and Quantification
Resources
RELEVANT CONCEPTS OF CANCER MEDICINE AND BIOLOGY
Classification and Epidemiology
Cellular Proliferation and Communication
Genetic Abnormalities in Cancer
Tumor Immunology
Diagnosis and Treatment
Some Pertinent Experimental Methods
METABOLISM AND BIOMARKERS OF CARCINOGENS

Classification, Mechanisms of Action and Biomarkers
Occupational Carcinogens
Environmental Carcinogens
DNA Damage by Radiation and Oxidation
ANTINEOPLASTIC AND CHEMOPREVENTIVE AGENTS
Cytotoxic Therapy

Endocrine Therapy

Targeted Drug Delivery and Therapy

Nutritional and Chemical Prevention

STRATEGIES, TECHNIQUES AND APPLICATIONS IN CANCER BIOCHEMISTRY AND BIOLOGY

Proteins and Peptides
Lipids
Oligonucleotides and Nucleic Acids
Carbohydrates and Glycoconjugates
REFERENCES
INDEX