An Handbook of Industrial Mycology

1. Auflage 2004
ISBN: 978-1-135-52697-9
Verlag: CRC Press
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 784 Seiten

Reihe: Mycology

Several excellent books have been published that address one or more aspects of the diverse field of industrial mycology, but none of them cover the entire process of fungal bioactive metabolites discovery. Until now. The Handbook of Industrial Mycology provides, in one volume, an overview of recent developments in industrial mycology with emphasis on the discovery of bioactive metabolites and, most importantly, their underlying biology and genetics. Two additional features distinguish this book from other books in the field: 1) most chapters are prepared using experimental data to illustrate theories and 2) the authors provide methodologies and experimental protocols in their chapters.

Presenting a comprehensive overview of recent advances, the book provides a framework of basic methods, tools, and organizational principles for channeling fungal germplasm into the academic, pharmaceutical, and enzyme discovery laboratories. It covers the complex range of processes involved in the discovery, characterization, and profiling of bioactive fungal metabolites. The book includes examples of several recently marketed fungal metabolites and explores the impact of fungi on applications in the pharmaceutical, food and beverage, agricultural, and agrochemical industries.

Zielgruppe

Microbiologists, mycologists, biotechnologists, bioengineers, bioprocess technologists, biochemists, and graduate students in these disciplines

Autoren/Hrsg.

An, Zhiqiang

Fachgebiete

• Naturwissenschaften Biowissenschaften Botanik
• Naturwissenschaften Chemie Chemie Allgemein
• Naturwissenschaften Biowissenschaften Mikrobiologie

Inhaltsverzeichnis

MYCOLOGY, INDUSTRIAL MYCOLOGY, AND FUNGAL BIOLOGY
Industrial Mycology: Past, Present and Future
Phylogeny of the Fungal Kingdom and Fungal-like Eukaryotes
Biological Activities of Fungal Metabolites
Cell Cycle Regulation in Morphogenesis and Development of Fungi
Agrobacterium-Mediated Transformation of Filamentous Fungi

FUNGAL SECONDARY METABOLITES DISCOVERY
Fungal Germplasm for Drug Discovery and Industrial Applications
Expression of Cosmid-Size DNA of Slow-Growing Fungi in Aspergillus nidulans for Secondary Metabolite Screening
The Isolation and Structure Elucidation of Fungal Metabolites
PCR-Based Data and Secondary Metabolites as Chemotaxonomical Markers in High Throughput Screening for Bioactive Compounds from Fungi
Screening for Biological Activities in Fungal Extracts
Sordarins, Inhibitors of Fungal Elongation Factor 2

BIOSYNTHESIS OF FUNGAL SECONDARY METABOLITES
Secondary Metabolite Gene Clusters
The Aflatoxin Biosynthetic Pathway
Indole-Diterpene Biosynthesis in Ascomycetous Fungi
Loline and Ergot Alkaloids in Grass Endophytes
Biosynthesis of N-methylated peptides in fungi
The Molecular Genetics of Lovastatin and Compactin Biosynthesis
The Aspergillus nidulans Polyketide Synthase WA

FERMENTATION, STRAIN IMPROVEMENT, AND BIOCONVERSION
Pneumocandin B0 Production by Fermentation of the Fungus Glarea lozoyensis: Physiological and Engineering Factors Affecting Titer and Structural-Analogue Formation
Strain Improvement for the Production of Secondary Metabolites
Fungal Bioconversions: Applications to the Manufacture of Pharmaceuticals

METABOLIC ENGINEERING
Metabolomics
Metabolic Engineering Fungal Secondary Metabolic Pathways

HETEROLOGOUS PROTEIN AND ENZYME EXPRESSION IN FUNGI
Heterologous Protein and Enzyme Expression in Fungi

MYCOTOXIN
Toxigenic Fungi and Mycotoxin

FUNGI IN BIOLOGICAL CONTROL
Biochemical Basis of Fungi in Biocontrol of Plant Diseases