Buch, Englisch, 240 Seiten, Format (B × H): 161 mm x 241 mm, Gewicht: 499 g
Buch, Englisch, 240 Seiten, Format (B × H): 161 mm x 241 mm, Gewicht: 499 g
ISBN: 978-0-8493-4780-1
Verlag: CRC Press
This book presents information from different scientific disciplines - behavioral, biochemical, electrophysiological, anatomical, and medical - to detail the interaction of the neurotransmitter dopamine (DA) with other neurotransmitters or neuromodulators in the brain. Internationally recognized experts discuss the interaction of DA with monoaminergic transmitters such as norepinephrine, GABA, acetylcholine, and serotonin, as well as neuropeptide neurotransmitters/neuromodulators such as neurotensin, cholecystokinin, and the opioid peptides. This is also the first book to include data from positron emission tomography (PET) studies examining the interaction of neurotransmitters in the brain.
Zielgruppe
Professional
Autoren/Hrsg.
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Weitere Infos & Material
The Modulation of Dopaminergic Neurotransmission by Norepinephrine. Introduction. The Effects of NE Agonists and Antagonists on DA Cells in the Ventral Tegmental Area (VTA) and Substantia Nigra Pars Compacta (SNC): Electrophysiological Studies. The Effect of Experimental Manipulations of NE and DA Levels in the Brain: Microdialysis and Postmortem Studies. The Effect of NE Agonists and Antagonists on DA Release from Brain Slices. The Effect of the Acute and Chronic Administration of Adrenergic Compounds on DA Utilization, Synthesis, and Turnover: Postmortem Studies. The Effect of NE Agents on DA-Mediated Behaviors. The Effect of NE Neuronal Lesions on Cortical DA. Effect of Cortical NE Innervation on Regulation of D1 Receptors in the Prefrontal Cortex. Role of NE/DA Interactions in the "Ventral Tegmental Area" Syndrome. Conclusions. Acknowledgments. References. Dopamine-Opioid Interactions in the Basal Forebrain. Abbreviations. Introduction. Anatomical Evidence for a Dopamine-Opioid Interaction. Biochemical Evidence for a Dopamine-Opioid Interaction. Electrophysiological Evidence for Dopamine-Opioid Interactions. Behavioral Evidence for Dopamine-Opioid Interactions. Conclusions. References. Serotonergic Modulation of Midbrain Dopamine Systems. Introduction. Anatomy. DA/5-HT Hypothesis of Schizophrenia. MDMA: Dual Role for DA and 5-HT. Further Evidence for Interactions between 5-HT and DA. Conclusions. Acknowledgments. References. Electrophysiological and Biochemical Interactions Between Dopamine and Cholecystokinin in the Brain. Introduction. DA Neurons Containing CCK-8S. CCK Receptors. Electrophysiological Effects of CCK Peptides and Antagonists. Biochemical Interactions Between CCK and DA. Clinical Relevance of CCK. Significance of DA/CCK-8S Colocalization. References. The Modulation of Midbrain Dopaminergic Systems by GABA. Historical Perspective. GABA Receptors. Localization of GABA Receptors within the Substantia Nigra. GABAergic Terminals in the Substantia Nigra. Effects of GABA on DA Cell Physiology. Conclusions. A Strategy for Measuring Neurotransmitter Interactions in Vivo with Positron Emission Tomography (PET): Neuropsychiatric Implications. Introduction. Definition of the Conceptual Framework. Neurotransmitter Activity and Interactions Measured with PET: Experimental Data. Implications of the Experimental Approach. Summary and Future Directions
