Autophagy and Senescence in Cancer Therapy

Erscheinungsjahr 2021
ISBN: 978-0-12-824158-5
Verlag: William Andrew Publishing

Buch, Englisch, 382 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 750 g

Advances in Cancer Research, Volume 150, the latest release in this ongoing series, covers the relationship(s) between autophagy and senescence, how they are defined, and the influence of these cellular responses on tumor dormancy and disease recurrence. Specific sections in this new release include Autophagy and senescence, converging roles in pathophysiology, Cellular senescence and tumor promotion: role of the unfolded protein response, autophagy and senescence in cancer stem cells, Targeting the stress support network regulated by autophagy and senescence for cancer treatment, Autophagy and PTEN in DNA damage-induced senescence, mTOR as a senescence manipulation target: A forked road, and more.

Zielgruppe

<p>The volume is appropriate for scientists and physician-scientists who are interested in how tumor cells respond to cancer therapeutics and potentially evade the cell killing effects of standard of care therapy. </p>

Autoren/Hrsg.

Weitere Mitwirkende

Gewirtz, David A.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Virologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

1.Autophagy and senescence in cancer therapy
Nipa H. Patel, Sarah Bloukh, Enas Alwohosh, Ahmad Alhesa, Tareq Saleh, and David A. Gewirtz
2. Targeting the stress support network regulated by autophagy and senescence for cancer treatment
Jaejin Kim, Yeonghyeon Lee, Kyeonghwan Roh, Mi-Sung Kim, and Chanhee Kang
3. Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
Andrew R.J. Young, Liam D. Cassidy, and Masashi Narita
4. Autophagy and senescence: Insights from normal and cancer stem cells
Sarmistha Talukdar, Swadesh K. Das, Luni Emdad, and Paul B. Fisher
5. The role of autophagy in escaping therapy-induced polyploidy/senescence
Magdalena Dudkowska, Karolina Staniak, Agnieszka Bojko, and Ewa Sikora
6. Autophagy and PTEN in DNA damage-induced senescence
Arishya Sharma and Alexandru Almasan
7. Cellular senescence and tumor promotion: Role of the Unfolded Protein Response
Olivier Pluquet and Corinne Abbadie
8. mTOR as a senescence manipulation target: A forked road
Sarah Saoudaoui, Monique Bernard, Guillaume B. Cardin, Nicolas Malaquin, Apostolos Christopoulos, and Francis Rodier

Über Autor(innen)

Gewirtz, David A.
Dr. Gewirtz received his PhD degree from Mt. Sinai School of Medicine of the City University of New York. He has been at Virginia Commonwealth University in the Department of Pharmacology and Toxicology and as a member of the Massey Cancer Center for his entire career. His work has been in the areas of cancer chemotherapy and radiotherapy, originally in breast cancer, but more recently extending to lung cancer, prostate cancer and head and neck cancer. His interests have long been in the nature of alternative tumor responses to therapy, most prominently autophagy and senescence. He has long argued that senescence is not an irreversible form of growth arrest, that senescence could represent one form of tumor dormancy and furthermore that recovery from senescence could contribute to disease recurrence. His most recent publication describes the impact of the senolytic agent, ABT-263 (navitoclax) on breast and lung tumor cells induced into senescence by cancer chemotherapy and radiation.