Comparative Gene Finding

Models, Algorithms and Implementation
2. Auflage 2015
ISBN: 978-1-4471-6692-4
Verlag: Springer

Buch, Englisch, Band 20, 382 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 7273 g

Reihe: Computational Biology

This book presents a guide to building computational gene finders, and describes the state of the art in computational gene finding methods, with a focus on comparative approaches. Fully updated and expanded, this new edition examines next-generation sequencing (NGS) technology. The book also discusses conditional random fields, enhancing the broad coverage of topics spanning probability theory, statistics, information theory, optimization theory and numerical analysis. Features: introduces the fundamental terms and concepts in the field; discusses algorithms for single-species gene finding, and approaches to pairwise and multiple sequence alignments, then describes how the strengths in both areas can be combined to improve the accuracy of gene finding; explores the gene features most commonly captured by a computational gene model, and explains the basics of parameter training; illustrates how to implement a comparative gene finder; examines NGS techniques and how to build a genome annotation pipeline.

Zielgruppe

Research

Autoren/Hrsg.

Axelson-Fisk, Marina

Fachgebiete

• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik

Inhaltsverzeichnis

Introduction.- Single Species Gene Finding.- Sequence Alignment.- Comparative Gene Finding.- Gene Structure Submodels.- Parameter Training.- Implementation of a Comparative Gene Finder.- Annotation Pipelines for Next Generation Sequencing Projects.