Backert Inflammasome Signaling and Bacterial Infections

1. Auflage 2016
ISBN: 978-3-319-41171-2
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 397, 282 Seiten, eBook

Reihe: Current Topics in Microbiology and Immunology

This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens ( Salmonella , Shigella , Yersinia , Listeria and Helicobacter ), respiratory pathogens ( Mycobacterium , Legionella , Burkholderia and Streptococcus ) as well as skin and soft tissue pathogens ( Francisella and Staphylococcus ). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic.

Zielgruppe

Research

Autoren/Hrsg.

Backert, Steffen

Inhaltsverzeichnis

General strategies in inflammasome biology  (overview).- Structural mechanisms in inflammasome assembly and signaling.- Salmonella enterica inflammasome.- Yersinia pestis inflammasome.- Shigella flexneri inflammasome.- Helicobacter pylori inflammasome.- Listeria monocytogenes inflammasome.- Legionella pneumophila inflammasome.- Mycobacterium inflammasome.- Burkholderia pseudomallei inflammasome.- Streptococcus pneumoniae inflammasome.- Franciscella tularensis inflammasome.- Staphylococcus aureus inflammasome.

Über Autor(innen)

Steffen Backert is a professor at Erlangen/Nuremberg University (Germany), Chair of Microbiology.