The Pancreas

An Integrated Textbook of Basic Science, Medicine, and Surgery
4th Auflage
ISBN: 978-1-119-87597-0
Verlag: Wiley

Buch, Englisch, 1360 Seiten, Format (B × H): 224 mm x 278 mm, Gewicht: 2926 g

The PANCREAS
The newest edition of the essential guide to pancreatic medicine

The fourth edition of The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery integrates the cutting-edge research of recent years to update its presentation of this fast-growing subject. It details every known disorder of the pancreas, grounding them in a thorough understanding of pancreatic function, enhanced with high quality illustration and graphs. It also includes step-by-step guidance for relevant endoscopic techniques and surgical procedures.
The Pancreas readers will also find: - New comprehensive insights into three pancreatic diseases: autoimmune pancreatitis, cystic neoplasms, and neuroendocrine tumors
- An editorial team with decades of clinical and research experience in the US, Europe, and Asia
- Over 500 downloadable illustrations for use in scientific presentations

The Pancreas is a foundational reference for clinicians and researchers in gastroenterology and gastrointestinal surgery.

Autoren/Hrsg.

Beger, Hans G

Buchler, Markus W

Hruban, Ralph H

Mayerle, Julia

Neoptolemos, John P

Shimosegawa, Tooru

Warshaw, Andrew L

Whitcomb, David C

Zhao, Yupei

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Hepatologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gastroentereologie, Proktologie

Inhaltsverzeichnis

About the Companion Website xvii

Section 1 Anatomy of the Pancreas 1

1 Development of the Pancreas and Related Structures 3
Brian Lewis and Junhao Mao

2 Anatomy, Histology, and Fine Structure of the Pancreas 9
Daniel S. Longnecker and Elizabeth D. Thompson

3 Congenital and Inherited Anomalies of the Pancreas 23
Heiko Witt and Martin Zenker

Section 2 Physiology and Pathophysiology of Pancreatic Functions 33

4 Physiology of Acinar Cell Secretion 35
Ole H. Petersen

5 Physiology of Duct Cell Secretion 48
Wei- Yin Lin, Paramita Sarkar, and Shmuel Muallem

6 Physiology and Pathophysiology of Function of Sphincter of Oddi 56
Savio George Barreto and James Toouli

7 Neurohormonal and Hormonal Control of Pancreatic Secretion 65
Chung Owyang and Matthew J. DiMagno

8 Regulation of Pancreatic Protein Synthesis and Growth 75
Maria Dolors Sans and John A. Williams

9 Fibrogenesis in the Pancreas: The Role of Pancreatic Stellate Cells 86
Minoti V. Apte, Romano C. Pirola, and Jeremy S. Wilson

10 Pancreatic Endocrine–Exocrine Relationship 98
Kenichiro Furuyama and Yoshiya Kawaguchi

Section 3 Acute Pancreatitis 105

11 Epidemiology and Etiology of Alcohol- Induced Pancreatitis 107
Jeremy S. Wilson, Romano C. Pirola, and Minoti V. Apte

12 Epidemiology and Etiology of Biliary Acute Pancreatitis 119
Ippei Ikoma, Ko Tomishima, and Hiroyuki Isayama

13 Genetic Factors in Acute Pancreatitis 128
Mitchell L. Ramsey and Georgios I. Papachristou

14 The Role of the Intestine and Mesenteric Lymph in the Development of Organ Dysfunction in Severe Acute Pancreatitis 138
Alistair B.J. Escott, Anthony R.J. Phillips, and John A. Windsor

15 The Role of Neurogenic Inflammation in Pancreatitis 146
Metrah Mohammad Nader and Jami L. Saloman

16 Molecular, Biochemical, and Metabolic Abnormalities of Acute Pancreatitis 155
Ujjwal M. Mahajan, F. Ulrich Weiss, Markus M. Lerch, and Julia Mayerle

17 Histopathology of Acute Pancreatitis 164
Günter Klöppel

18 Severity Classification of Acute Pancreatitis 170
John A. Windsor

19 Clinical Assessment and Biochemical Markers to Objectify Severity and Prognosis 176
Bettina M. Rau and Claus Schäfer

20 Acute Pancreatitis Associated with Congenital Anomalies 185
Charlotte S. Austin, Christopher R. Schlieve, Andrew L. Warshaw, and Tracy C. Grikscheit

21 Acute Pancreatitis in Children 191
Mark E. Lowe and Véronique D. Morinville

22 Acute Pancreatitis Associated with Metabolic, Infections and Drug- Related Diseases 199
Ali A. Aghdassi, Mats L. Wiese, Quang Trung Tran, and Markus M. Lerch

23 Radiologic Diagnosis and Staging of Severe Acute Pancreatitis 208
Yoshihisa Tsuji

24 Conservative Therapy of Acute Pancreatitis: Volume Substitution and Enteral and Parenteral Nutrition 222
Steven M. Hadley, Jr. and Timothy B. Gardner

25 ICU Treatment of Severe Acute Pancreatitis 230
Scott R. Gunn and David C. Whitcomb

26 Clinical Course and Medical Treatment of Acute Pancreatitis— Use of Antibiotics in Severe Acute Pancreatitis: Indications and Limitations 238
Rainer Isenmann and Mathias Wittau

27 Indications for Interventional and Surgical Treatment of Necrotizing Pancreatitis 244
Lily V. Saadat and Thomas E. Clancy

28 Management of Infected Necrosis: Step- Up Approach 254
Hester C. Timmerhuis, Marc G. Besselink, and Hjalmar C. van Santvoort

29 Management of Infected Pancreatic Necroses: An Endoscopic Approach 260
Todd H. Baron

30 Minimally Invasive Debridement and Lavage of Necrotizing Pancreatitis 266
Kulbir Mann and Michael G.T. Raraty

31 Open Surgical Debridement of Necrotizing Pancreatitis: Late Postoperative Morbidity and Outcome 271
Dongya Huang, Zipeng Lu, and Yi Miao

32 Endoscopic Treatment of Acute Biliary Pancreatitis 278
Ichiro Yasuda, Tsuyoshi Mukai, and Toru Ito

33 Strategies for the Treatment of Pancreatic Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Interventional Endoscopic Approaches 284
Georg Beyer and Julia Mayerle

34 Pseudocysts and Walled- Off Necrosis After Acute Pancreatitis: Surgical Approach 288
Naohiro Sata, Masaru Koizumi, and Alan Kawarai Lefor

35 Management of Fluid Collection in Acute Pancreatitis 294
Georg Beyer, Simon Sirtl, Christoph Ammer- Herrmenau, and Albrecht Neesse

36 Management of Pancreatic Fistula in Acute Pancreatitis 300
Marta Sandini, Thilo Hackert, and Markus W. Büchler

37 Long- Term Outcome After Acute Pancreatitis 306
Christin Tjaden and Thilo Hackert

Section 4 Chronic Pancreatitis 315

38 Definition and Classification of Chronic Pancreatitis 317
David C. Whitcomb

39 Molecular Understanding of Chronic Pancreatitis 326
Bomi Lee, Monique T. Barakat, and Sohail Z. Husain

40 Natural History of Recurrent Acute and Chronic Pancreatitis 334
Rohit Das, Jorge D. Machicado, and Dhiraj Yadav

41 Pediatric Recurrent Acute and Chronic Pancreatitis: Role of Pancreas Divisum 344
Jiri Snajdauf, Michal Rygl, Barbora Kucerova, and Natalia Newland

42 Clinical and Laboratory Diagnosis of Chronic Pancreatitis 349
Georg Beyer, Markus M. Lerch, and Julia Mayerle

43 Abdominal Imaging for the Diagnosis of Chronic Pancreatitis 357
Atsushi Irisawa and Akira Yamamiya

44 Endoscopic Ultrasound for Diagnosis of Chronic Pancreatitis Versus Pancreatic Cancer 366
J. Enrique Domínguez- Muñoz, Julio Iglesias- García, José Lariño- Noia, and Daniel de la Iglesia- García

45 Hereditary Pancreatitis and Complex Genetic Causes 375
Celeste Shelton Ohlsen and David C. Whitcomb

46 Epidemiology and Pathophysiology of Tropical Chronic Pancreatitis 383
Shailesh V. Shrikhande and Savio G. Barreto

47 CFTR- Associated Pancreatic Disease 390
Chee Y. Ooi and Aliye Uc

48 Alcohol and Smoking in Chronic Pancreatitis 396
Atsushi Masamune, Kazuhiro Kikuta, and Kiyoshi Kume

49 Idiopathic and Rare Causes of Chronic Pancreatitis 404
Morihisa Hirota and Tooru Shimosegawa

50 Early Chronic Pancreatitis 412
Kazuhiro Kikuta and Atsushi Masamune

51 Chronic Pancreatitis with Inflammatory Mass in the Pancreatic Head 418
Ulrich F. Wellner, Kim C. Honselmann, and Tobias Keck

52 Structural Complications: Strictures, Stones, Pseudocysts, and Vascular Complications 424
Xiaodong Tian, Xiaochao Guo, and Yinmo Yang

53 Nutritional Evaluation and Support: An Overview 430
Sinead N. Duggan and Stephen J. O’Keefe

54 Exocrine Pancreatic Insufficiency 436
Chris E. Forsmark

55 Bone Disease in Chronic Pancreatitis 442
Sinead N. Duggan

56 Diabetes from Exocrine Pancreatic Disease 445
Nao Fujimori, Tetsuhide Ito, and Yoshihiro Ogawa

57 Oxidative Stress and Antioxidants in Chronic Pancreatitis 451
Soumya Jagannath Mahapatra and Pramod Kumar Garg

58 Pain Mechanisms in Chronic Pancreatitis 460
Pierluigi Di Sebastiano, Fabio Francesco di Mola, Tommaso Grottola, and Rossana Percario

59 Pain Management in Chronic Pancreatitis 467
Louise Kuhlmann, Søren S. Olesen, and Asbjørn M. Drewes

60 Adjunctive Therapy in Chronic Pancreatitis 474
Anna Evans Phillips

61 Pancreatic Cancer Risks in Chronic Pancreatitis 480
Patrick Maisonneuve and Albert B. Lowenfels

62 Evidence of Endoscopic and Interventional Treatment of Chronic Pancreatitis and Pseudocysts 486
Jörg Schirra, Simon Sirtl MD, Markus M. Lerch, and Julia Mayerle

63 Major Pancreatic Resection for Chronic Pancreatitis: Indication, Goals, and Limitations 496
Faik G. Uzunoglu and Jakob R. Izbicki

64 Pancreatic Drainage Procedures: Techniques and Results 501
Ulrich F. Wellner, Dirk Bausch, and Tobias Keck

65 Duodenum- Preserving Pancreatic Head Resections for Chronic Pancreatitis: Techniques and Results 506
Hans G. Beger, Bertram Poch, Yang Yinmo, and Waldemar Uhl

66 Total Pancreatectomy with Islet Autotransplant 515
Greg Beilman, Zachary Bergman, and Melena Bellin

67 Minimally Invasive Surgical Management of Chronic Pancreatitis 523
Gilbert Z. Murimwa, Herbert J. Zeh III, and Matthew R. Porembka

Section 5 Autoimmune Pancreatitis 533

68 Epidemiology of Autoimmune Pancreatitis 535
Terumi Kamisawa

69 Molecular Immunology and Pathogenesis of Autoimmune Pancreatitis 540
Yoh Zen

70 Clinical Manifestation of Type 1 Autoimmune Pancreatitis 546
Tooru Shimosegawa

71 Clinical Manifestation of Type 2 Autoimmune Pancreatitis 554
Nicolò de Pretis and Luca Frulloni

72 Clinical Diagnostic Criteria for Autoimmune Pancreatitis 561
Tooru Shimosegawa

73 Laboratory Diagnosis of Autoimmune Pancreatitis 568
J- Matthias Löhr and Miroslav Vujasinovic

74 What is the Evidence Measuring Immune Markers 573
Shigeyuki Kawa, Takayuki Watanabe, and Norihiro Ashihara

75 Autoimmune Pancreatitis and IgG4- Related Disease 579
Kazuichi Okazaki, Tsukasa Ikeura, and Kazushige Uchida

76 Imaging Diagnosis of Autoimmune Pancreatitis 595
Kazuichi Okazaki, Makoto Takaoka, Tsukasa Ikeura, and Kazushige Uchida

77 Medical Management of Autoimmune Pancreatitis 600
Shounak Majumder and Suresh T. Chari

78 Management of Intractable Autoimmune Pancreatitis 605
Shounak Majumder and Suresh T. Chari

79 Long- Term Outcome After Treatment of Autoimmune Pancreatitis 609
Luca Frulloni and Nicolò de Pretis

Über Autor(innen)

Hans G. Beger, MD, FACS (Hon.), JSS (Hon.), CSS (Hon.), Professor Emeritus of Surgery, University of Ulm, Ulm, Germany.
Markus W. Büchler, MD, FACS (Hon.), FRCS (Hon.), FASA (Hon.) Professor of Surgery, University of Heidelberg, Heidelberg, Germany.
Ralph H. Hruban, MD, Baxley Professor and Director, Department of Pathology and Director of the Sol Goldman Pancreatic Research Center, Johns Hopkins University School of Medicine, Baltimore, USA.
Julia Mayerle, MD, Professor of Internal Medicine, Gastroenterology and Hepatology, Chair Department of Medicine II, LMU Klinikum, Ludwig-Maximilians-University, Munich, Germany.
John P. Neoptolemos, MA, MB, BCHIR, MD FRCS, FMEDSCI, MAE Professor of Surgery, Department of Surgery, University of Heidelberg, Heidelberg, Germany.
Tooru Shimosegawa, MD, PhD, Professor Emeritus Department of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Andrew L. Warshaw, MD, FACS, FRCSEd (Hon.), W. Gerald Austen Distinguished Professor of Surgery, Harvard Medical School, and Surgeon-in-Chief Emeritus, Massachusetts General Hospital, Boston, USA.
David C. Whitcomb, MD, PhD, Professor of Medicine, Cell Biology & Physiology, and Human Genetics, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh and UPMC, Pennsylvania, USA.
Yupei Zhao, MD, FICS (Hon.), FACS (Hon.), FRCS (Engl) (Hon.), FCSHK (Hon.), Professor of Surgery, Department of General Surgery, Peking Union Medical College Hospital, Beijing, P.R. China.