Modern Techniques in Protein NMR

2002
ISBN: 978-1-4757-8081-9
Verlag: Springer US

Buch, Englisch, Band 16, 387 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 622 g

Reihe: Biological Magnetic Resonance

Volume 16 marks the beginning of a special topic series devoted to modern techniques in protein NMR, under the Biological Magnetic Resonance series. This volume is being followed by Volume 17 with the subtitle Structure Computation and Dynamics in Protein NMR. Volumes 16 and 17 present some of the recent, significant advances in biomolecular NMR field with emphasis on developments during the last five years. We are honored to have brought together in these volumes some of the world’s foremost experts who have provided broad leadership in advancing this field. Volume 16 contains advances in two broad categories: the first, Large Proteins, Complexes, and Membrane Proteins, and second, Pulse Methods. Volume 17, which will follow covers major advances in Computational Methods, and Structure and Dynamics. In the opening chapter of Volume 16, Marius Clore and Angela Gronenborn give a brief review of NMR strategies including the use of long range restraints in the structure determination of large proteins and protein complexes. In the next two chapters, Lewis Kay and Ron Venters and their collaborators describe state-of-t- art advances in the study of perdeuterated large proteins. They are followed by Stanley Opella and co-workers who present recent developments in the study of membrane proteins. (A related topic dealing with magnetic field induced residual dipolar couplings in proteins will appear in the section on Structure and Dynamics in Volume 17).

Zielgruppe

Research

Autoren/Hrsg.

Berliner, Lawrence J.

Krishna, N. Rama

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Physik Quantenphysik Atom- und Molekülphysik
• Naturwissenschaften Chemie Physikalische Chemie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Bildgebende Verfahren, Nuklearmedizin, Strahlentherapie Radiologie, Bildgebende Verfahren

Inhaltsverzeichnis

Large Proteins, Complexes, and Membrane Proteins.- Determining Structures of Large Proteins and Protein Complexes by NMR.- Multidimensional 2H-Based NMR Methods for Resonance Assignment, Structure Determination, and The Study of Protein Dynamics.- NMR of Perdeuterated Large Proteins.- Recent Developments in Multidimensional NMR Methods for Structural Studies of Membrane Proteins.- Pulse Methods.- Homonuclear Decoupling in Proteins.- Pulse Sequences for Measuring Coupling Constants.- Methods for the Determination of Torsion Angle Restraints in Biomacromolecules.

Über Autor(innen)

is Professor of Biochemistry and Molecular Genetics and the Director of the NMR Core Facility at the University of Alabama at Birmingham. He has previously served as Guest Editor for Volumes 16 (, 1998) and Volume 17 (, 1999). is currently Professor and Chair of the Department of Chemistry and Biochemistry at the University of Denver after retiring from Ohio State University, where he spent a 32-year career in the area of biological magnetic resonance (EPR and NMR). He is the Series Editor for , which he launched in 1979.