Oral Delivery of Macromolecular Drugs

Barriers, Strategies and Future Trends
2009
ISBN: 978-1-4419-0199-6
Verlag: Springer

Buch, Englisch, 242 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 600 g

Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.

Zielgruppe

Research

Autoren/Hrsg.

Bernkop-Schnürch, Andreas

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tierphysiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Kosmetische Technologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie

Inhaltsverzeichnis

Enzymatic Barriers.- Gastrointestinal Mucus Gel Barrier.- The Absorption Barrier.- Strategies to Overcome the Enzymatic Barrier.- Low Molecular Mass Permeation Enhancers in Oral Delivery of Macromolecular Drugs.- Polymeric Permeation Enhancers.- Strategies to Overcome Efflux Pumps.- Multifunctional Polymeric Excipients in Oral Macromolecular Drug Delivery.- Nano- and Microparticles in Oral Delivery of Macromolecular Drugs.- Liposome-Based Mucoadhesive Formulations for Oral Delivery of Macromolecules.- Strategies in Oral Immunization.- Oral Delivery of Nucleic Acid Drugs.

Über Autor(innen)

Andreas Bernkop-Schnürch is the Dean of the Faculty of Chemistry and Pharmacy and Professor of Pharmaceutical Technology at the University of Innsbruck, Austria. His main interests focus on non-invasive drug delivery systems, multifunctional polymers such as thiomers, mucoadhesion and permeation enhancement. He is author of more than 200 original research and review articles and received the Research-Award of the City of Vienna (Vienna), EURAND-Award (Boston), Best of Biotech Award (Vienna), MBPW-Award (Munich), PHÖNIX Award (Mannheim), Houska-Award (Vienna) and Austrian-Nanoaward (Vienna). In addition, Andreas Bernkop-Schnürch is founder and owner of the following companies: ThioMatrix GmbH, Dr. K. Schnürch KG and Green River Polymers GmbH.