E-Book, Englisch, 424 Seiten
Berstein G Protein-Coupled Receptors
Erscheinungsjahr 2010
ISBN: 978-1-4200-4851-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
E-Book, Englisch, 424 Seiten
Reihe: Methods in Signal Transduction Series
ISBN: 978-1-4200-4851-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction.
G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors.
This volume is useful at both the university and industrial levels, and is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.
Zielgruppe
Audience: Pharmacologists, neuroscientists, biochemists, industrial scientists and molecular biologists
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
NOVEL LIGANDS: LIGAND SCREENING SYSTEMS AND ORPHAN RECEPTORS
Measurement of Competitive and Allosteric Interactions in Radioligand Binding Studies-S. Lazareno and N.Birdsall
Ligand Screening of G Protein-Coupled Receptors in Yeast-J. Hadcock and M. Pausch
Ligand Screening Using Melanophore Cells: Frog Skin to Combinatorial Chemistry-J. Quillan and M. Hadley
Screening Orphan Receptors for Native Ligands-S. Wilson, et al.
FUNCTION AND REGULATION: RECEPTOR-G PROTEIN COUPLING AND DESENSITIZATION
Reconstitution of Receptor-Promoted Signal Transduction Using Purified Receptor, G Protein, and Effector-G. Berstein and G. Biddlecome
Mutagenesis Approaches for Studying Receptor-G Protein Interactions and Receptor Assembly-F. Zeng, et al.
G Protein-Coupled Receptor Kinases and Desensitization of Receptors-H. Kurose
Internalization and Down regulation of G Protein-Coupled Receptors-J. Lameh
Use of Electrophysiology to Monitor and Study Receptor Desensitization-M. Boyett, Z. Shui, and I. Khan
3D STRUCTURE: LARGE-SCALE EXPRESSION AND ELECTRON AND X-RAY CRYSTALLOGRAPHY
Expression in Escherichia coli and Large-Scale Purification of a Rat Neurotensin Receptor-R. Grisshammer and J. Tucker
Large-Scale Expression of Receptors in Yeasts-H. Reilander, C. Reinhart, and A. Szmolenszky
Electron Crystallography of Membrane Proteins-Y. Fujiyoshi
X-Ray Crystallography of Membrane Proteins from Detergent Solution: The Structures of a Ligand-Gated Bacterial Membrane Receptor in Two Conformations: a Gallery at Atomic Resolution-K. Locher, B. Rees, D. Moras, and J. Rosenbusch
X-Ray Crystallography of Membrane Proteins: Concepts and Applications of Lipidic Mesophases to Three-Dimensional Membrane Protein Crystallization-M. Loewen. M. Chiu, C. Widmer, E. Landau, J. Rosenbusch, and P. Nollert
