Fatty Acid and Lipotoxicity in Obesity and Diabetes

1. Auflage 2008
ISBN: 978-0-470-05764-3
Verlag: Wiley

Buch, Englisch, 222 Seiten, Format (B × H): 159 mm x 235 mm, Gewicht: 482 g

Reihe: Novartis Foundation Symposium

Metabolic diseases such as obesity, diabetes and hypertension are among the most common chronic illnesses and major causes of morbidity worldwide. These diseases are due to alterations of basic metabolic pathways such as those for glucose and lipids, and they are extremely costly to treat. Because of their

increasing prevalence they have attracted tremendous attention from the scientific community in recent years and significant advances have been made in our understanding of their molecular nature.

* The potential lipotoxic effect of accumulation of fatty acids in non-adipose issue is thought to be a major component in the development of insulin resistance.

* Chronic exposure to elevated free fatty acids affects pancreatic ß cell function, insulin secretion and lipid synthesis in the liver, and storage in adipose tissue.

* Maintaining the normal levels of fatty acids requires coordinated regulation between the liver, adipose tissue and skeletal muscle.

This book presents an integrated approach to the problems of obesity and type 2 diabetes and carefully examines the role that fatty acids and lipids play in the development and progression of these diseases and in the transition from one to the other. Topics covered include lipid metabolism, adipose tissue biology, ß cell function and insulin resistance. Specific chapters also deal with the molecular genetics and molecular physiology of energy homeostasis. Fatty Acids and Lipotoxicity in Obesity and Diabetes will be of interest to anyone working on the causes of obesity and diabetes.

Autoren/Hrsg.

Bock, Gregory R

Goode, Jamie A

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Diabetologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie

Inhaltsverzeichnis

Bruce M. Spiegelman Chair's introduction

Bruce M. Spiegelman Transcriptional control of energy homeostasis through

the PGC1 coactivators

Discussion

Stephen O'Rahilly Human obesity and insulin resistance: lessons from

experiments of nature

Discussion

Deborah M. Muoio and Timothy R. Koves Lipid-induced metabolic

dysfunction in skeletal muscle

Discussion

Alan D. Attie, Matthew T. Flowers, Jessica B. Flowers, Albert K. Groen,

Folkert Kuipers and James M. Ntambi Stearoyl-CoA desaturase

deficiency, hypercholesterolaemia, cholestasis and diabetes

Discussion

Karen Reue The role of lipin 1 in adipogenesis and lipid metabolism

Discussion

David Carling The role of the AMP-activated protein kinase in the regulation

of energy homeostasis

Discussion

Gökhan S. Hotamisligil Endoplasmic reticulum stress and inflammation in

obesity and type 2 diabetes

Discussion

Ira Tabas, Tracie Seimon, Jerry Arellano, Yankun Li, Fabien Forcheron,

Dongying Cui, Seongah Han, Chien-Ping Liang, Alan Tall and

Domenico Accili The impact of insulin resistance on macrophage death

pathways in advanced atherosclerosis

Discussion

Sandra Lobo and David A. Bernlohr Fatty acid transport in adipocytes and

the development of insulin resistance

Discussion

Paul N. Black and Concetta C. DiRusso Vectorial acylation: linking fatty

acid transport and activation to metabolic trafficking

Discussion

Günther Daum, Andrea Wagner, Tibor Czabany, Karlheinz Grillitsch and

Karin Athenstaedt Lipid storage and mobilization pathways in yeast

Discussion

John Zhong Li and Peng Li Cide proteins and the development of

obesity

Discussion

General discussion I

Visualizing brown adipose tissue with FDG-PET

Takashi Kadowaki, Toshimasa Yamauchi, Naoto Kubota, Kazuo Hara and

Kohjiro Ueki Adiponectin and adiponectin receptors in obesity-linked

insulin resistance

Discussion

Gabriel Pascual, Amy L. Sullivan, Sumito Ogawa, Amir Gamliel,

Valentina Perissi, Michael G. Rosenfeld and Christopher K. Glass

Anti-inflammatory and antidiabetic roles of PPAR³

Discussion

Final discussion

Nutrition, ageing and lipotoxicity

Index of contributors

Subject index