E-Book, Englisch, 328 Seiten
Reihe: Reproductive Medicine & Assisted Reproductive Techniques
Borini / Coticchio Preservation of Human Oocytes
Erscheinungsjahr 2009
ISBN: 978-0-203-09287-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
From Cryobiology Science to Clinical Applications
E-Book, Englisch, 328 Seiten
Reihe: Reproductive Medicine & Assisted Reproductive Techniques
ISBN: 978-0-203-09287-3
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
Oocyte cryopreservation entails important potential advantages for human
IVF, offering a less ethically disputable alternative to embryo cryopreservation,
simplifying and making safer oocyte donation, and giving an opportunity for
fertility preservation to women at risk of premature ovarian failure as an effect
of genetic factors or chemo- or radiotherapies. Oocyte cryopreservation could
also meet the expectations of women wishing to preserve their fertility for
social reasons. In the last few years, advances in cryopreservation
methodologies have dramatically improved the efficiency of oocyte
cryopreservation, leading to the birth of over a thousand babies and
challenging the supremacy of embryo cryopreservation as the preferred
form of fertility preservation. This text has been conceived with the aim of offering a comprehensive view of the state of the art of oocyte cryopreservation. It covers fundamental concepts of low temperature storage (controlled rate slow cooling and
vitrification), aspects of oocyte physiology relevant to the process of
cryopreservation, essential biological and clinical evidence, and ethical
implications of oocyte cryopreservation, thereby providing a complete
overview of progress in this strategy in assisted reproduction.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Part I: Fundamental cryobiology 1. A historical overview of embryo and oocyte preservation in the world of mammalian in vitro fertilization and biotechnology 2. Principles of cryobiology 3. Rational basis of controlled rate cooling 4. Fundamentals and current practice of vitrification 5. Predictive models for the development of improved cryopreservation protocols for human oocytes Part II: Biological aspect of oocyte cryopreservation 6. Natural life cycle of the mammalian oocyte 7. Essential features of the mature oocyte 8. Expression of functional aquaporins in oocytes and embryos and the impact on cryopreservation 9. Oocyte storage at different developmental stages 10. Oocyte cyopreservation in the mouse 11. Oocyte storage in domestic species 12. Control of the solution effect during controlled rate cooling: principles and practical application 13. Cryopreservation and the cytoskeleton of the human oocyte 14. Non-invasive assessment of cryopreserved oocytes through polarized light microscopy 15. Impact of cryopreservation on oocyte physiology, metabolism and the proteome Part III: Laboratory, clinical, and ethical aspects of oocyte storage 16. Quality management of a low temperature storage program in the human IVF laboratory 17. The contribution of embryo cryopreservation in the clinical efficacy of ART and to a reduction of ART multiple pregnancies 18. Factors influencing the clinical efficiency of oocyte cryopreservation 19. Early and recent history of oocyte cryopreservation in human IVF 20. Success rates from oocyte cryopreservation 21. Clinical evidence of oocyte vitrification 22. The impact of oocyte storage for fertility preservation before radio- and chrmotherapy 23. Impact of oocyte storage in oocyte donation treatments 24. The health of babies from cryopreserved oocytes and embryos 25. The ethics of fertility preservation
