Bradley / Harris / Jenner International Review of Neurobiology

1. Auflage 2005
ISBN: 978-0-08-045831-1
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 63, 312 Seiten, Web PDF

Reihe: International Review of Neurobiology

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

Autoren/Hrsg.

Jenner, Peter

Bradley, Ronald J.

Harris, R. Adron

Inhaltsverzeichnis

1;front cover;1
2;copyright;5
3;table of contents;6
4;contributors;9
5;MAPPING NEURORECEPTORS AT WORK: ON THE DEFINITION AND INTERPRETATION OF BINDING POTENTIALS AFTER 20 YEARS OF PROGRESS;11
5.1;I. Twenty Years of Progress;11
5.2;II. Remaining Issues;19
5.3;III. Solutions;29
5.4;References 1;29
6;MITOCHONDRIAL DYSFUNCTION IN BIPOLAR DISORDER: FROM MAGNETIC RESONANCE SPECTROSCOPIC FINDINGS TO THEIR MOLECULAR MECHANISMS;31
6.1;I. Introduction 2;31
6.2;II. Phosphorus-31 Magnetic Resonance Spectroscopy;32
6.3;III. Near-Infrared Spectroscopy;36
6.4;IV. Molecular Genetic Findings;38
6.5;V. Roles of Mitochondrial Calcium Regulation;43
6.6;VI. Conclusions;44
6.7;References 2;45
7;LARGE-SCALE MICROARRAY STUDIES OF GENE EXPRESSION IN MULTIPLE REGIONS OF THE BRAIN IN SCHIZOPHRENIA AND ALZHEIMER’S DISEASE;51
7.1;I. Introduction 3;51
7.2;II. Gene Expression Profiling Using Microarrays: Technologies Overview;53
7.3;III. Postmortem Brains and Gene Expression Studies;59
7.4;IV. Comparison of Gene Expression Profiles among Normal Brain Regions;67
7.5;V. Gene Expression Profiles of Brain Regions in Alzheimer’s Disease;69
7.6;VI. Gene Expression Profiling in Schizophrenia;73
7.7;VII. Future Perspectives;78
7.8;References 3;80
8;REGULATION OF SEROTONIN 2C RECEPTOR PRE-mRNA EDITING BY SEROTONIN;93
8.1;I. Introduction 4;93
8.2;II. Modification of RNA Sequences by RNA Editing via Hydrolytic Deaminations of Adenosines;94
8.3;III. Enzymes Responsible for A-to-I Editing and Their Substrate Requirements;96
8.4;IV. A-to-I Editing of the 5- HT2C Receptor Pre- mRNA;97
8.5;V. Modulation of 5- HT2C Receptor Function by RNA Editing;98
8.6;VI. 5- HT2C Pre- mRNA Editing Responses to Sustained Changes of Postsynaptic 5-HT2C Receptor Activation;101
8.7;VII. 5- HT2C Pre- mRNA Editing in the Human Prefrontal Cortex and Alterations in Editing-Site Preferences in Brains of Subjects with Major Depression;103
8.8;VIII. Conclusions and Future Directions;106
8.9;References 4;107
9;THE DOPAMINE HYPOTHESIS OF DRUG ADDICTION: HYPODOPAMINERGIC STATE;111
9.1;I. Drug Addiction as a Brain Disease;112
9.2;II. The Mesolimbic Dopamine System;115
9.3;III. Behavioral Animal Models;125
9.4;IV. Biochemical Studies;130
9.5;V. Primate Studies;136
9.6;VI. Conclusions;140
9.7;Acknowledgments 5;140
9.8;References 5;141
10;HUMAN AND ANIMAL SPONGIFORM ENCEPHALOPATHIES ARE AUTOIMMUNE DISEASES: A NOVEL THEORY AND ITS SUPPORTING EVIDENCE;165
10.1;I. Introduction 6;165
10.2;II. A New Theory on the Mechanism of Pathogenesis of Spongiform Encephalopathies (SEs);168
10.3;III. Supporting Evidence;179
10.4;IV. Early Diagnosis, Treatment, and Prevention of Various SE Diseases;190
10.5;V. Conclusions;192
10.6;Acknowledgments 6;194
10.7;References 6;194
11;ADENOSINE AND BRAIN FUNCTION;201
11.1;I. Introduction 7;202
11.2;II. Regulation of Brain Adenosine Levels in the Central Nervous System;202
11.3;III. Adenosine Receptors;206
11.4;IV. Functions of Adenosine Receptors;218
11.5;V. Adenosine–Dopamine Interactions in Brain;222
11.6;VI. Phenotypes of Knockout Mice;226
11.7;VII. Adenosine Receptors and Protection against Ischemic and Excitotoxic Brain Injuries;233
11.8;VIII. Adenosine A2A Receptors and Neurodegenerative Disorders;238
11.9;IX. Adenosine Receptors and Psychiatric Disorders;244
11.10;X. Adenosine and the Regulation of Sleep– Wake Cycles;246
11.11;XI. Adenosine and Epilepsy;248
11.12;XII. Adenosine and Pain;250
11.13;Acknowledgments 7;251
11.14;References 7;251
12;Index;281
13;Contents of Recent Volumes;292