Gene Therapy for Neurological Disorders and Brain Tumors

1998
ISBN: 978-0-89603-507-2
Verlag: Humana Press

Buch, Englisch, 458 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 1193 g

Reihe: Contemporary Neuroscience

Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

Zielgruppe

Research

Autoren/Hrsg.

Breakefield, Xandra O.

Chiocca, E. Antonio

Fachgebiete

• Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik
• Naturwissenschaften Biowissenschaften Biowissenschaften Neurobiologie, Verhaltensbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Sozialwissenschaften Psychologie Allgemeine Psychologie Biologische Psychologie, Neuropsychologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gentherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion

Inhaltsverzeichnis

1 Retrovirus Vectors and Regulatable Promoters.- 2 Characteristics of Adenovirus Vectors.- 3 HSV Recombinant Vectors: General Characteristics and Potential for Use in the Central Nervous System.- 4 HSV-1 Amplicon.- 5 AAV Vectors: General Characteristics and Potentialfor Use in the Central Nervous System.- 6 EBV Vectors: General Characteristics and Potential for Gene Therapy in the Central Nervous System.- 7 Lentiviral Vectors for Gene Delivery in the Central Nervous System.- 8 Promoters for Expression of Gene Products Within Neurons and Glia.- 9 Immune Response to Viral Vectors.- 10 Current Treatment Modalities for Brain Tumor: Surgery, Radiation, and Chemotherapy.- 11 Experimental and Clinical Gene Therapies for Brain Tumors.- 12 Tumor Suppressor Gene Therapy for Brain Tumors.- 13 Cytokine-Based Gene Therapy for Brain Tumors.- 14 Delivery of Therapeutic Genes to Brain and Intracerebral Tumors.- 15 Rat Brain Tumor Models and Statistical Evaluation of Survival Data in Experimental Neuro-Oncology.- 16 Gene Transfer for Adult CNS Regeneration and Aging.- 17 Gene Therapy for Parkinson’s Disease.- 18 Gene Therapy for Ischemic Stroke.- 19 Gene Therapy for the Lysomal Storage Diseases.- 20 Gene Therapy for Pain.- 21 Gene Therapy of Huntington’s Disease.