Brenner / Hung Cancer Gene Therapy by Viral and Non-viral Vectors

1. Auflage 2014
ISBN: 978-1-118-50165-8
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 176 Seiten, E-Book

Reihe: Translational Oncology

Provides expert, state-of-the-art insight into the currentprogress of viral and non-viral gene therapy
Translational medicine has opened the gateway to the era ofpersonalized or precision medicine. No longer a one-size-fits-allapproach, the treatment of cancer is now based on an understandingof underlying biologic mechanisms and is increasingly beingtailored to the molecular specificity of a tumor.
This book provides a comprehensive overview of the pertinentmolecular discoveries in the cancer field and explains how theseare being used for gene-based cancer therapies. Designed as avolume in the Translational Oncology book series, Cancer GeneTherapy by Viral and Non-viral Vectors deals with the practiceof gene-therapy, with reference to vectors for gene expression andgene transfer, as well as viral therapy. It covers the history andcurrent and future applications of gene transfer in cancer, andprovides expert insight on the progress of viral and non-viral genetherapy with regard to delivery system, vector design, potentialtherapeutic genes, and principles and regulations for cancer genetherapy.
Presented in three parts, Cancer Gene Therapy by Viral andNon-viral Vectors covers:
Delivery Systems
* Translational Cancer Research: Gene Therapy by Viraland Non-viral Vectors
* Retroviruses for Cancer Therapy
* DNA Plasmids for Non-viral Gene Therapy ofCancer
* Cancer Therapy with RNAi delivered by Non-viralMembrane/Core Nanoparticles
Targeted Expression
* Cancer Gene Therapy by Tissue-specific andCancer-targeting Promptors
* MicroRNAs as Drugs and Drug Targets in Cancer
Principles of Clinical Trials in Gene Therapy
* Regulatory issues for Manufacturers of Viral Vectorsand Vector-transduced Cells for Phase I/II Trials
* US Regulations Governing Clinical Trials in GeneTherapy
* Remaining Obstacles to the Success of Cancer GeneTherapy
Focusing on speeding the process in clinical cancer care bybringing therapies as quickly as possible from bench to bedside,Cancer Gene Therapy by Viral and Non-viral Vectors is anabsolutely vital book for physicians, clinicians, researchers, andstudents involved in this area of medicine.

Autoren/Hrsg.

Brenner, Malcolm

Hung, Mien-Chie

Inhaltsverzeichnis

List of Contributors, vii
Series Foreword, ix
Preface, xi
Part I Delivery Systems
1 Translational Cancer Research: Gene Therapy by Viral andNon-viral Vectors, 3
Vincenzo Cerullo, Kilian Guse, Markus Vähä-Koskela,and Akseli Hemminki
2 Retroviruses for Cancer Therapy, 21
Jiehua Zhou, Yue Ding, John C. Burnett, and John Rossi
3 DNA Plasmids for Non-viral Gene Therapy of Cancer, 39
Amer M. Najjar, Judy S.E. Moyes, and Laurence J.N.Cooper
4 Cancer Therapy with RNAi Delivered by Non-viral Membrane/CoreNanoparticles, 61
Andrew B. Satterlee and Leaf Huang
Part II Targeted Expression
5 Cancer Gene Therapy by Tissue-specific and Cancer-targetingPromoters, 81
Jennifer L. Hsu, Longfei Huo, Chia-Wei Li, Yi-Hsin Hsu, YanWang, and Mien-Chie Hung
6 MicroRNAs as Drugs and Drug Targets in Cancer, 97
Hui Ling and George A. Calin
Part III Principles of Clinical Trials in GeneTherapy
7 Regulatory Issues for Manufacturers of Viral Vectors andVector-transduced Cells for Phase I/II Trials, 115
Adrian P. Gee and Zhuyong Mei
8 US Regulations Governing Clinical Trials in Gene Therapy,131
Bambi Grilley
9 Remaining Obstacles to the Success of Cancer Gene Therapy,151
Malcolm K. Brenner
Index, 157

Über Autor(innen)

Edited by
Malcolm K. Brenner, MB, BChir, PhD, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA
Mien-Chie Hung PhD, Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA