Buch, Englisch, 117 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 371 g
Buch, Englisch, 117 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 371 g
Reihe: Nanotechnology in the Life Sciences
ISBN: 978-3-030-43854-8
Verlag: Springer International Publishing
Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome.
Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use.
This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
- Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Medizinische Mikrobiologie & Virologie
- Naturwissenschaften Agrarwissenschaften Ackerbaukunde, Pflanzenbau Nutzpflanzen: Biologie, Genetik, Pflanzenzüchtung
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
- Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
- Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik
- Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde Materialwissenschaft: Biomaterialien, Nanomaterialien, Kohlenstoff
Weitere Infos & Material
Preface.- 1. Antimicrobial screening, foundations and interpretation.- 2. Antimicrobial activity of nanomaterials, from selection to application.- 3. Synergy and antagonism, the criteria of the formulation.- 4. In vitro Nanotoxicity, towards the development of safe and effective treatments.- 5. ADMETox, bringing nanotechnology closer to Lipinski's rule of five.- 6. Antimicrobial nanotechnology in preventing the transmission of infectious disease.- 7. Nanotechnology in the discovery of new antimicrobial drugs: is a new scientific revolution possible?.- 8. Nanotechnology beyond the antibiosis.- Index.
