Cell Death Regulation in Health and Disease - Part A

Erscheinungsjahr 2020
ISBN: 978-0-12-820133-6
Verlag: William Andrew Publishing

Buch, Englisch, 252 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 520 g

Cell Death Regulation in Health and Disease - Part A, Volume 351, the latest release in the International Review of Cell and Molecular Biology reviews current advances in cell and molecular biology. The series publishes timely topics authored by prominent cell and molecular biologists. This release is part of a 3-part series which comprises a comprehensive view of cell death regulation in a variety of biological contexts. Chapters cover Membrane dynamics in cell death regulation, The role of necroptosis in intestinal dysfunction, Regulation of cell death in the cardiovascular system, Cell death in bacterial and viral infection, and much more.

Zielgruppe

<p>Expert investigators who may wish to expand their knowledge of the biology of regulated cell death, and to newcomers to this exciting and rapidly expanding area of research</p>

Autoren/Hrsg.

Weitere Mitwirkende

Spetz, Johan K.E.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Preface: Life through death: Key role of cellular suicide for colonial and organismal homeostasis Johan Spetz and Lorenzo Galluzzi

1. Bcl-2 family proteins, beyond the veil Jason Andrew Glab, Zhipeng Cao and Hamsa Puthalakath

2. Mcl-1 as a "barrier� in cancer treatment: Can we target it now? Nikolai V. Pervushin, Viacheslav V. Senichkin, Boris Zhivotovsky and Gelina S. Kopeina

3. TRAIL receptor signaling: From the basics of canonical signal transduction toward its entanglement with ER stress and the unfolded protein response Daniela St�hr, Albert Jeltsch and Markus Rehm

4. Type 3 IP3 receptors: The chameleon in cancer Nicolas Rosa, Flore Sneyers, Jan B. Parys and Geert Bultynck

5. On the role of sphingolipids in cell survival and death Elisabetta Iessi, Matteo Marconi, Valeria Manganelli, Maurizio Sorice, Walter Malorni, Tina Garofalo and Paola Matarrese

6. A lipid perspective on regulated cell death Hector Flores-Romero, Uris Ros and Ana J. Garc�a S�ez

Über Autor(innen)

Spetz, Johan K.E.
Johan Spetz (born 1986) is currently a postdoctoral research fellow at the John B. Little Center for Radiation Sciences at Harvard T.H. Chan School of Public Health. With a background as a Medical Physicist (M.Sc. 2010, University of Gothenburg), Johan Spetz's PhD (2017, University of Gothenburg) focused on peptide receptor radionuclide therapy of small intestine neuroendocrine tumors and biological effects of radiation. This research prompted a further interest in biology, and lead Johan Spetz to enter a postdoctoral research position under the mentorship of Kristopher Sarosiek at Harvard T.H. Chan School of Public Health, with a focus on the regulation of apoptotic priming in response to stress such as irradiation. Specifically, Johan Spetz has worked on measuring dynamic regulation of apoptotic sensitivity in healthy as well as cancerous mammalian cells throughout development and aging, on a single cell level. Through this research, Johan Spetz has identified subsets of cells which are vulnerable to genotoxic stress, within otherwise resistant tissues. Johan Spetz has also worked on the development of functional assays to measure defects in the intrinsic apoptotic pathway, which may be targeted to enhance cancer therapeutics and/or reduce toxic side effects of treatment. Johan Spetz has published 19 articles in peer-reviewed scientific journals and 90+ scientific conference abstracts.