Cell Death Regulation in Health and Disease - Part B

Erscheinungsjahr 2020
ISBN: 978-0-12-819929-9
Verlag: William Andrew Publishing

Buch, Englisch, 230 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 340 g

Cell Death Regulation in Health and Disease - Part B, Volume 352, the latest release in the International Review of Cell and Molecular Biology, reviews and details current advances in cell and molecular biology. Chapters in this updated release include Regulation of cell death signaling in insects, Bcl-2 family proteins, Cell death signaling in prokaryotes, Parthanatos in neurodegenerative diseases, Cell death regulation in yeast, Mutual regulation of autophagy and necroptosis, Therapeutic inhibition of cell death by autophagy induction, and Necroptosis in neurodegenerative diseases.

Zielgruppe

<p>Expert investigators who may wish to expand their knowledge of the biology of regulated cell death, and to newcomers to this exciting and rapidly expanding area of research</p>

Autoren/Hrsg.

Weitere Mitwirkende

Spetz, Johan K.E.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Preface: Life through death-Key role of cellular suicide for colonial and organismal homeostasis

Johan Spetz and Lorenzo Galluzzi

1. The mechanisms and cell signaling pathways of programmed cell death in the bacterial world

Robert P. Smith, Ivana Barraza, Rebecca J. Quinn and Marla C. Fortoul

2. Transcriptional and epigenetic control of regulated cell death in yeast

Andreas Zimmermann, Jelena Tadic, Katharina Kainz, Sebastian J. Hofer, Maria A. Bauer, Didac Carmona-Gutierrez and Frank Madeo

3. Cell death in the avian brain with emphasis on the development and plasticity of the song control system

Tracy A. Larson

4. Crosstalk between apoptosis and autophagy signaling pathways

W. Douglas Fairlie, Sharon Tran and Erinna F. Lee

5. The interplay of autophagy and non-apoptotic cell death pathways

Dannah R. Miller, Scott D. Cramer and Andrew Thorburn

6. Redox signaling in the pathogenesis of human disease and the regulatory role of autophagy

Shazib Pervaiz, Gregory L. Bellot, Antoinette Lemoine and Catherine Brenner

Über Autor(innen)

Spetz, Johan K.E.
Johan Spetz (born 1986) is currently a postdoctoral research fellow at the John B. Little Center for Radiation Sciences at Harvard T.H. Chan School of Public Health. With a background as a Medical Physicist (M.Sc. 2010, University of Gothenburg), Johan Spetz's PhD (2017, University of Gothenburg) focused on peptide receptor radionuclide therapy of small intestine neuroendocrine tumors and biological effects of radiation. This research prompted a further interest in biology, and lead Johan Spetz to enter a postdoctoral research position under the mentorship of Kristopher Sarosiek at Harvard T.H. Chan School of Public Health, with a focus on the regulation of apoptotic priming in response to stress such as irradiation. Specifically, Johan Spetz has worked on measuring dynamic regulation of apoptotic sensitivity in healthy as well as cancerous mammalian cells throughout development and aging, on a single cell level. Through this research, Johan Spetz has identified subsets of cells which are vulnerable to genotoxic stress, within otherwise resistant tissues. Johan Spetz has also worked on the development of functional assays to measure defects in the intrinsic apoptotic pathway, which may be targeted to enhance cancer therapeutics and/or reduce toxic side effects of treatment. Johan Spetz has published 19 articles in peer-reviewed scientific journals and 90+ scientific conference abstracts.