Cell Death Regulation in Health and Disease - Part C

Erscheinungsjahr 2020
ISBN: 978-0-12-820135-0
Verlag: William Andrew Publishing

Buch, Englisch, 298 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 610 g

Cell Death Regulation in Health and Disease - Part C, Volume 353 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series maintains the highest standard by publishing timely topics authored by prominent cell and molecular biologists, with this release covering Developmental and seasonal regulation of neural cell death in birds, Post-translational modifications in cell death regulation, The role of cell death in tissue regeneration and fibrosis, Crosstalk between the apoptosis and autophagy signaling pathways, IP3 receptor signal integration in cell death and survival decisions, and more.

Zielgruppe

<p>Expert investigators who may wish to expand their knowledge of the biology of regulated cell death, and to newcomers to this exciting and rapidly expanding area of research</p>

Autoren/Hrsg.

Weitere Mitwirkende

Spetz, Johan K.E.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

Preface - Life through death: Key role of cellular suicide for colonial and organismal homeostasis Johan K.E. Spetz and Lorenzo Galluzzi 1. Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases Hyejin Park, Tae-In Kam, Ted M. Dawson and Valina L. Dawson 2. Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases Pedro A. Dionísio, Joana D. Amaral and Cecília M.P. Rodrigues 3. Necroptosis, ADAM proteases and intestinal (dys)function Michelle Heib, Stefan Rose-John and Dieter Adam 4. Regulation of cell death in the cardiovascular system Pooja Patel and Jason Karch 5. The involvement of regulated cell death forms in modulating the bacterial and viral pathogenesis Gergely Imre 6. A connection in life and death: The BCL-2 family coordinates mitochondrial network dynamics and stem cell fate  Megan L. Rasmussen and Vivian Gama

Über Autor(innen)

Spetz, Johan K.E.
Johan Spetz (born 1986) is currently a postdoctoral research fellow at the John B. Little Center for Radiation Sciences at Harvard T.H. Chan School of Public Health. With a background as a Medical Physicist (M.Sc. 2010, University of Gothenburg), Johan Spetz's PhD (2017, University of Gothenburg) focused on peptide receptor radionuclide therapy of small intestine neuroendocrine tumors and biological effects of radiation. This research prompted a further interest in biology, and lead Johan Spetz to enter a postdoctoral research position under the mentorship of Kristopher Sarosiek at Harvard T.H. Chan School of Public Health, with a focus on the regulation of apoptotic priming in response to stress such as irradiation. Specifically, Johan Spetz has worked on measuring dynamic regulation of apoptotic sensitivity in healthy as well as cancerous mammalian cells throughout development and aging, on a single cell level. Through this research, Johan Spetz has identified subsets of cells which are vulnerable to genotoxic stress, within otherwise resistant tissues. Johan Spetz has also worked on the development of functional assays to measure defects in the intrinsic apoptotic pathway, which may be targeted to enhance cancer therapeutics and/or reduce toxic side effects of treatment. Johan Spetz has published 19 articles in peer-reviewed scientific journals and 90+ scientific conference abstracts.