Chagas Disease

Part B
1. Auflage 2011
ISBN: 978-0-12-385896-2
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 76, 294 Seiten

Reihe: Advances in Parasitology

This thematic volume provides authoritative, up-to-date reviews addressing recent advances as well as an overview for the research and clinical communities on the endemic infection of Chagas disease. Lead researchers discuss epidemiology and control measures as well as various diagnosis techniques, treatments, and therapies currently being used. The text includes a history of Chagas disease and an outlook for the next century. - Informs and updates on all the latest developments in the field - Contributions from leading authorities and industry experts

Autoren/Hrsg.

Inhaltsverzeichnis

1;Front Cover;1
2;Chagas Disease, Part B;4
3;Copyright;5
4;Contents of Volume 76;6
5;Contents of Volume 75;10
6;Contributors of Volume 76;16
7;Preface;22
7.1;References;26
8;Chapter 1: Bioactive Lipids in Trypanosoma cruzi Infection;28
8.1;1.1. Introduction;30
8.2;1.2. Eicosanoid Synthesis in Vertebrates;31
8.3;1.3. Lipid Metabolism and Eicosanoid Biosynthetic Pathways in Trypanosoma cruzi;37
8.4;1.4. Endogenous Regulation of Eicosanoids During Experimental Chagas Disease;39
8.5;1.5. Lessons from Pharmacological Manipulation and from Null Mice;44
8.6;Acknowledgements;50
8.7;References;51
9;Chapter 2: Mechanisms of Host Cell Invasion by Trypanosoma cruzi;60
9.1;2.1. Introduction;61
9.2;2.2. General Features of Trypanosoma cruzi Invasion;63
9.3;2.3. To the Lysosome and Beyond;68
9.4;2.4. Disruption of the Parasitophorous Vacuole Membrane and Cytosolic Localization of Parasites;76
9.5;2.5. The Role of the Host Cell Cytoskeleton in Trypanosoma cruzi Trypomastigote Invasion of Non-Phagocytic Cells...;78
9.6;2.6. The Discovery of Reversible Invasion;80
9.7;2.7. Concluding Remarks;81
9.8;References;81
10;Chapter 3: Gap Junctions and Chagas Disease;90
10.1;3.1. Introduction;91
10.2;3.2. Loss of Gap Junctions and Coupling in Rodent Chagasic Cardiomyopathy;93
10.3;3.3. Not All Junctional Proteins are Affected by Trypanosoma cruzi Infection;101
10.4;3.4. Microarray Experiments have Revealed Profound Changes in Gene Expression in the Chagasic Mouse, Both in Acute and in Chro;101
10.5;3.5. Conclusions;103
10.6;References;106
11;Chapter 4: The Vasculature in Chagas Disease;110
11.1;4.1. Historical Aspects;111
11.2;4.2. Small Animal Studies of the Microcirculation in Trypanosoma cruzi Infection;113
11.3;4.3. Studies in Dogs;115
11.4;4.4. Vasoactive Peptides and Eicosanoids;116
11.5;4.5. In Vitro Studies;118
11.6;4.6. Studies in Humans;119
11.7;4.7. Conclusions;121
11.8;Acknowledgements;122
11.9;References;122
12;Chapter 5: Infection-Associated Vasculopathy in Experimental Chagas Disease: Pathogenic Roles of Endothelin and Kinin Pathway;128
12.1;5.1. Introduction;130
12.2;5.2. A Brief Overview on the Immunopathogenesis of Chagas Disease;130
12.3;5.3. Future Directions;145
12.4;Acknowledgements;147
12.5;References;147
13;Chapter 6: Autoimmunity;156
13.1;6.1. Introduction;157
13.2;6.2. Natural History of Chagas Disease;161
13.3;6.3. Heart-Specific Inflammatory Lesions in CCC: Parasite Antigen-Driven Immunopathology?;161
13.4;6.4. Immunopathogenesis of CCC;162
13.5;6.5. Autoimmunity in Chagas Disease;164
13.6;6.6. Molecular Mimicry;167
13.7;6.7. Conclusion;169
13.8;References;171
14;Chapter 7: ROS Signalling of Inflammatory Cytokines During Trypanosoma cruzi Infection;180
14.1;7.1. Reactive Oxygen Species and Source;181
14.2;7.2. Inflammatory Cytokines During Trypanosoma cruzi Infection and Chagas Disease;183
14.3;7.3. ROS Signalling of Cytokine Responses;185
14.4;7.4. The Impact of Oxidative Stress and Cytokine Mediators and Cardiac Dysfunction;187
14.5;7.5. Conclusions and Future Directions;189
14.6;Acknowledgements;190
14.7;References;191
15;Chapter 8: Inflammation and Chagas Disease: Some Mechanisms and Relevance;198
15.1;8.1. The Multiple Roles of Inflammation in Chagas Disease;199
15.2;8.2. Experimental Models for Studying Inflammation and Immune Mechanisms in Chagas Disease;200
15.3;8.3. Mediators of Protection in Experimental Trypanosoma cruzi Infection;203
15.4;8.4. Mediators of Inflammation and Their Role in Mediating Tissue Damage and Protection in Experimental Trypanosoma cruzi Infection;204
15.5;8.5. Conclusion;213
15.6;Acknowledgements;214
15.7;References;214
16;Chapter 9: Neurodegeneration and Neuroregeneration in Chagas Disease;222
16.1;9.1. Introduction;223
16.2;9.2. Involvement of the Autonomic Nervous System in CD Pathogenesis;224
16.3;9.3. Mechanism of Neuronal Damage;229
16.4;9.4. Neuroregeneration;233
16.5;9.5. Trans-Sialidase/Parasite-Derived Neurotrophic Factor;236
16.6;9.6. Conclusions;247
16.7;References;248
17;Chapter 10: Adipose Tissue, Diabetes and Chagas Disease;262
17.1;10.1. Introduction;263
17.2;10.2. Adiponectin;264
17.3;10.3. Adipose Tissue and Infection;267
17.4;10.4. Chagas Disease and Adipose Tissue;268
17.5;10.5. Chagas Disease and Glycaemia;272
17.6;10.6. Conclusions;273
17.7;Acknowledgements;273
17.8;References;273
18;Contents of Volumes in this Series;278
19;Index;290
20;Colour Plate;296