Chayama Hepatitis C Virus Treatment

Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance
1. Auflage 2017
ISBN: 978-981-10-2416-0
Verlag: Springer Singapore
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 75 Seiten, eBook

This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects. Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Chayama, Kazuaki

Inhaltsverzeichnis

Preface The first generation protease inhibitor Telaprevir and the emergence of antiviral resistance Features of the second wave of the first generation protease inhibitors: effect and tolerance  Effects and resistance risks of combination treatment with Daclatasvir  + Asunaprevir: the first approved oral agent without IFN and ribavirin  Resistance features of NS5A inhibitors and methods for detection  Detection of naturally occurring variants with resistance features against antiviral drugs Incidence and characteristics of naturally occurring resistant strains Characteristics and resistance profiles of polymerase inhibitors  Emerging antivirals in the future

Über Autor(innen)

Prof. Kazuaki ChayamaDepartment of Gastroenterology and Metabolism, Applied Life Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University