Buch, Englisch, 400 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 540 g
Buch, Englisch, 400 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 540 g
ISBN: 978-0-08-043261-8
Verlag: Elsevier Science & Technology
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Chemie Organische Chemie Organometallchemie
- Naturwissenschaften Agrarwissenschaften Agrarwissenschaften Landwirtschaftliche Bewässerung
- Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Verfahrenstechnik, Chemieingenieurwesen
- Wirtschaftswissenschaften Wirtschaftssektoren & Branchen Primärer Sektor Agrarökonomie, Ernährungswirtschaft
Weitere Infos & Material
Introduction: scope and overview; organolithiums in solution. Regioselective synthesis of organolithiums by deprotonation: general points; lithiation alpha to heteroatoms; ortholithiation; lateral lithiation; remote lithiation, and beta-lithiation of non-aromatic compounds; superbases; co-operation, competition and regioselectivity. Regioselective synthesis of organolithiums by X-Li exchange: halogen-lithium exchange; tin-lithium exchange; chalcogen-lithium exchange; phosphorus-lithium exchange. Regioselective synthesis of organolithiums by C-X reduction: reductive lithiation of alkyl and aryl halides; reductive lithiation of C-O bonds; reductive lithiation of C-N bonds; reductive lithiation of C-S bonds; reductive lithiation of C-C bonds and pi-bonds. Stereoselective and stereospecific synthesis of organolithiums: configurational stability of organolithiums; Stereospecific synthesis of organolithiums by X-Li exchange; diastereoselective deprotonation; enantioselective deprotonation. Stereospecific and stereoselective substitution reactions of organolithiums: stereospecific reactions of organolithium compounds; stereoselective substitution in the presence of chiral ligands. Regio- and stereoselective addition reactions of organolithiums: intermolecular addition to pi bonds - carbolithiation; intramolecular addition and substitution reactions - anionic cyclization. Organolithium rearrangements: Shapiro reaction; Brook rearrangements; [1,2]-Wittig rearrangements; [2,3]-Wittig rearrangements. Organolithiums in synthesis: ochratoxin - ortholithiation and anionic Fries rearrangement; corydalic acid methyl ester - lateral lithiation; fredericamycin A - ortho, lateral and alpha-lithiation; (?)-Atpenin B - metallation of an aromatic heterocycle; flurbiprofen - metallation with LiCKOR superbases; California red scale pheromone - alpha- and reductive lithiation C1-C9 of the Bryostatins - diastereoselective bromine-lithium exchange; (S)-1-methyldodecyl acetate, a Drosophila pheromone - (-)-sparteine assisted enantioselective lithiation; (-)-Paroxetine - (-)-sparteine-promoted asymmetric lithiation and substitution.