Placebo and Pain

From Bench to Bedside
Erscheinungsjahr 2013
ISBN: 978-0-12-397928-5
Verlag: Elsevier Science

Buch, Englisch, 312 Seiten, Format (B × H): 220 mm x 284 mm, Gewicht: 1136 g

The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers' knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain.

Review for Placebo and Pain:"This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues.�--Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School

Zielgruppe

Pain remains one of the most common conditions studied by sensory and clinical neuroscience today, with approximately 3 to 4.5 percent of the global population suffering from chronic neuropathic pain. The placebo effect and its twin the nocebo effect are both of particular relevance to pain research, and there is now substantial evidence that these result from real neurobiological processes. Experimental and clinical studies have shed light on the neural structures underlying the pain state, but the role of placebo and nocebo have yet to be systematically explored in a comprehensive volume. <i> <p>Placebo and Pain </i>discusses the three major aspects of this research: laboratory investigations of the brain and bodily placebo analgesic responses, methodological aspects of placebo effects, and clinical implications for pain treatment and management. Authored and edited by the international leading experts in the field, the book provides the only accurate, up-to-date coverage on pain and placebo on the market today. </p>

Autoren/Hrsg.

Colloca, Luana

Flaten, Magne Arve

Meissner, Karin

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete AINS Schmerzmedizin & Schmerztherapie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Preface
1. Historical Aspects of Placebo Analgesia
2. Neurochemistry of Placebo Analgesia: Opioids, Cannabinoids and Cholecystokinin
3. Placebo Analgesia in Rodents
4. Molecular Mechanisms of Placebo Responses in Humans
5. How Does EEG Contribute to Our Understanding of the Placebo Response?
6. Spinal Mechanisms of Placebo Analgesia and Nocebo Hyperalgesia: Descending Inhibitory and Facilitatory Influences
7. Spinal and Supraspinal Mechanisms of Placebo Analgesia
8. Positive and Negative Emotions and Placebo Analgesia
9. Placing Placebo in Normal Brain Function with Neuroimaging
10. Brain Predictors of Individual Differences in Placebo Responding
11. Placebo Responses, Antagonistic Responses, and Homeostasis
12. Placebo Analgesia, Nocebo Hyperalgesia, and Acupuncture
13. The Relevance of Placebo and Nocebo Mechanisms for Analgesic Treatments
14. How Placebo Responses Are Formed: From Bench to Bedside
15. Methodologic Aspects of Placebo Research
16. Balanced Placebo Design, Active Placebos, and Other Design Features for Identifying, Minimilizing and Characterizing the Placebo Response
17. Psychological Processes that can Bias Responses to Placebo Treatment for Pain
18. Against "Placebo." The Case for Changing our Language, adn for the Meaning Response
19. Placebo Effects in Complementary and Alternative Medicine: The Self-Healing Response
20. Conceptualizations and Magnitudes of Placebo Analgesia Effects Across Meta-Analyses and Experimental Studies
21. The Contribution of Desire, Expectation, and Reduced Negative Emotions to Placebo Anti-Hyperalgesia in Irritable Bowel Syndrome
22. The Wound that Heals: Placebo, Pain and Surgery
23. What Are the Best Placebo Interventions for the Treatment of Pain?
24. How Communication between Clinicians and Patients may Impact Pain Perception
25. Nocebos in Daily Clinical Practice
26. The Potential of the Analgesic Placebo Effect in Clinical Practice - Recommendations for Pain Management
27. Placebo and Nocebo: Ethical Challenges and Solutions

Über Autor(innen)

Flaten, Magne Arve
Professor of Biological Psychology and Depatment Chair of Psychology at the Norwegian University of Science and Technology, Dr. Flaten's reserach focuses on biological psychology, psychology of learning, behavioral medicine, and pain. He serves as a board member for European Psychologist and European Journal of Behavior Analysis and served as Chair for the Organizing Committee of the International Conference on Imaging in Neuroscience 2007-2009. Dr. Flaten chaired the 2011 symposium on placebo and pain at the annual Society for Neuroscience meeting.