Pharmacology of Ketamine

Fundamentals, Applications, Delivery Systems and Clinical Aspects
Erscheinungsjahr 2025
ISBN: 978-0-443-29930-8
Verlag: Elsevier Science

Buch, Englisch, 500 Seiten, Format (B × H): 191 mm x 235 mm

Pharmacology of Ketamine: Fundamentals, Applications, Delivery Systems and Clinical Aspects explores the multifaceted properties of ketamine for diverse applications, delving into dosing strategies, routes of administration, and their pharmacological implications. The book begins with an introduction that underscores the need to bridge research and practice. It then delves into the pharmacological intricacies of ketamine, dissecting mechanisms and dosing strategies and exploring the diverse routes of administration and their impact on ketamine's metabolites.

The book then explores the PK and PD characteristics of ketamine, followed by a deep dive into clinical applications emphasizing anesthesia, psychiatric therapy, and emerging treatments. The final part of the book covers addiction, toxicity, and future research perspectives. It will serve as a comprehensive reference tailored to the needs of both researchers and clinicians involved in the administration and study of ketamine.

Autoren/Hrsg.

Dahan, Albert

Dadiomov, David

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1. Ketamine and its metabolites - mechanism of action
2. Ketamine pharmacokinetics and pharmacodynamics
3. Ketamine effects on brain dynamics
4. Ketamine for depression and other psychiatric diseases
5. Undestanding ketamine subjective effects
6. Ketamine for acute and chronic pain
7. Ketamine for neuropathic pain: animal and human studies
8. Ketamine for addiction treatment
9. Cardiorespiratory effects of ketamine
10. Ketamine toxicity: translating preclinical findings to adverse effects in humans
11. Recreational use of ketamine
12. Ketamine in the era of the opioid crisis
13. Future Perspectives

Über Autor(innen)

Dahan, Albert
Albert Dahan received his MD at the VuMC Amsterdam (1986) and his PhD in 1990 at Leiden University. The title of his dissertation was The ventilatory response to CO2 and O2 in man: methods and implications. Part of the research was performed in the US (UCLA).

After he became an anesthesiologist (1995), he worked at Leiden University Medical Center as anesthesiologist and founded the Anesthesia & Pain Reseacrh Unit. Research was and is performed in several facilities including the animal research lab, the cardiorespiratory lab, the pain lab and the OR and PACU.

He was appointed as professor is 2004 and gave his inaugural speech in 2005 (May 25, entitled Bij Kennis, or Awake with Wisdom).

Dahan is member of several prestigious American and European editorial boards, such as the of the US journals Anesthesiology, Pain and European Journal European Journal of Pain.

Dahan is member of several international advisory boards relating to perioperative care and opioids and is co-author of several internal guidelines.

Dadiomov, David
David Dadiomov, PharmD, BCPP, is a clinical assistant professor of pharmacy practice in the Titus Family Department of Clinical Pharmacy.

He received his PharmD from the University of Michigan College of Pharmacy. He completed his PGY1 Pharmacy Residency at Michigan Medicine, and his PGY2 Psychiatric Pharmacy Residency at University of California, San Diego, Health. He holds board certification in psychiatric pharmacy.

Dadiomov serves as the director of the PGY2 Psychiatric Pharmacy Residency Program. He maintains clinical practice in addiction medicine at Los Angeles General Medical Center. In this role he provides consultations in psychiatry and addiction as well as seeing patients in the Complex Care Clinic. Dadiomov has worked with the LA County Department of Health Services to establish novel clinical pharmacy services for patients experiencing homelessness, patients currently or recently released from incarceration, as well as those with severe mental illness and addiction disorders.