Buch, Englisch, 357 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 557 g
Buch, Englisch, 357 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 557 g
Reihe: Cancer Drug Discovery and Development
ISBN: 978-3-030-08627-5
Verlag: Springer International Publishing
The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Zielgruppe
Research
Autoren/Hrsg.
Fachgebiete
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
Weitere Infos & Material
Chapter 1 Introduction: Motivations for Next-Generation ADCs.- Chapter 2 Combining ADCs with Immuno-oncology Agents.- Chapter 3 Improving the Safety Profile of ADCs.- Chapter 4 Utility of PK-PD Modeling and Simulation to Improve Decision Making for Antibody-Drug Conjugate Development.- Chapter 5 Regulatory Considerations and Companion Diagnostics.- Chapter 6 ADC Process Development and Manufacturing.- Chapter 7 HER2-Targeted ADCs: At the forefront of ADC technology development.- Chapter 8 Next generation payloads for ADCs.- Chapter 9 Delivering more payload: High DAR ADCs.- Chapter 10 Site-Specific Antibody Drug Conjugates.- Chapter 11 Bispecific and Biparatopic Antibody-Drug Conjugates.- Chapter 12 drug conjugates to the tumor microenvironment: Probody Drug Conjugates.- Chapter 13 Antibody-Drug Conjugates: Targeting the Tumor Microenvironment.- Chapter 14 Next Horizons: ADCs Beyond Oncology.