Virus as Populations

Composition, Complexity, Quasispecies, Dynamics, and Biological Implications
2. Auflage 2019
ISBN: 978-0-12-816331-3
Verlag: William Andrew Publishing

Buch, Englisch, 426 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 790 g

Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included.

The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere.

Zielgruppe

<p>grad students, researchers, med students and investigators in virology, microbiology, and infectious disease; pharmacologists and vaccinologists; theoretical biologists; evolutionary biologists.</p>

Autoren/Hrsg.

Domingo, Esteban

Fachgebiete

• Naturwissenschaften Biowissenschaften Virologie
• Naturwissenschaften Biowissenschaften Mikrobiologie

Inhaltsverzeichnis

1. Introduction to Virus Origins and Their Role in Biological Evolution2. Molecular Basis of Genetic Variation of Viruses 3. Darwinian Principles Acting on Highly Mutable Viruses4. Dynamics of Virus Populations and Their Hosts5. Viral Fitness as a Measure of Adaptation 6. Virus Population Dynamics Examined with Experimental Model Systems 7. Long-term Virus Evolution in Nature8. Quasispecies Dynamics in Disease Prevention and Control9. Trends in Antiviral Strategies10. Collective Population Effects in Non-Viral Systems

Über Autor(innen)

Domingo, Esteban
Esteban Domingo studied chemistry and biochemistry at the University of Barcelona, Spain and spent postdoctoral stays at the University of California, Irvine and the University of Zürich. His main interests are the quasispecies structure of RNA viruses and the development of new antiviral strategies. He is presently Professor of Research of the Spanish Research Council (CSIC) at Centro de Biología Molecular "Servero Ochoa" in Madrid.