Dudoit / van der Laan Multiple Testing Procedures with Applications to Genomics
1. Auflage 2007
ISBN: 978-0-387-49317-6
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 590 Seiten, eBook
Reihe: Springer Series in Statistics
ISBN: 978-0-387-49317-6
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark
This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. These are applied to a range of problems in biomedical and genomic research, including identification of differentially expressed and co-expressed genes in high-throughput gene expression experiments; tests of association between gene expression measures and biological annotation metadata; sequence analysis; and genetic mapping of complex traits using single nucleotide polymorphisms. The procedures are based on a test statistics joint null distribution and provide Type I error control in testing problems involving general data generating distributions, null hypotheses, and test statistics.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Multiple Hypothesis Testing.- Test Statistics Null Distribution.- Overview of Multiple Testing Procedures.- Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn).- Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate.- Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates.- Simulation Studies: Assessment of Test Statistics Null Distributions.- Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments.- Multiple Tests of Association with Biological Annotation Metadata.- HIV-1 Sequence Variation and Viral Replication Capacity.- Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project.- Software Implementation.
