Myeloid-Derived Suppressor Cells and Cancer

1. Auflage 2016
ISBN: 978-3-319-26819-4
Verlag: Springer International Publishing

Buch, Englisch, 102 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 1825 g

Reihe: SpringerBriefs in Immunology

The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research.

Zielgruppe

Research

Autoren/Hrsg.

Escors, David

Talmadge, James E.

Kochan, Grazyna

Breckpot, Karine

Ginderachter, Jo A. van

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

Controversies in Neoplastic Myeloplasia.- Differentiation of Murine Myeloid-derived Suppressor Cells.- Human MDSCs.- Ex Vivo MDSC Differentiation Models.- Immunoregulatory myeloid cells in the tumor microenvironment.- Signal Transducer and Activation of Transcription 3: A Master Regulator of Myeloid-derived Suppressor Cells.- Future Perspectives.