Feinendegen / Shreeve / Eckelman Molecular Nuclear Medicine

The Challenge of Genomics and Proteomics to Clinical Practice
Erscheinungsjahr 2012
ISBN: 978-3-642-55539-8
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 795 Seiten, eBook

Nuclear Medicine techniques have advanced to such a degree that biochemical transparency of the human body has reached the doorstep of medical application. The book gives background, techniques and examples in an interdisciplinary approach to quantify biochemical reactions in vivo by regional imaging and in vitro analyses. The goal is to assess in vivo biochemical homeostatic circuits under control by genes and protein interactions. It becomes apparent how nuclear medicine can aid clinical researchers and practitioners, human geneticists and pharmacologists in understanding (and affecting) gene-phenotype relationships operating in vivo and thus can help eventually to bring functional genomics and proteomics to clinical medicine.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Feinendegen, L.E.

Shreeve, W.W.

Eckelman, W.C.

Bahk, Yong Whee

Wagner, H.N. Jr.

Inhaltsverzeichnis

I Primary Topics.- 1 Measurements of Biochemical Reactions in Vivo.- 2 The Human Genome and Disease.- 3 Functional Genomics and Proteomics: Basics, Opportunities and Challenges.- 4 How Proteins Speak with One Another in Cell Signaling.- 5 Labeled Agents as Tracers and Carriers: Theory and Practice.- 6 Instrumentation for Measuring Metabolism.- 7 Modelling Metabolite and Tracer Kinetics.- 8 Compound Delivery and Local Blood Flows.- II Whole Body Processes.- 9 Endothelium and Compound Transfer.- 10 Coagulation and Peripheral Vascular Disease.- 11 Molecular Imaging of Infection and Inflammation.- 12 Element Metabolism and Body Composition.- 13 The Biology of Aging and Related Nuclear Medicine Studies.- 14 In Vitro Indicators of Metabolism of Natural Compounds.- III Organ Systems.- 15 Endocrinology.- 16 Noninvasive Assessment of Inherited Cardiac Disease Using Positron Emission Tomography.- 17 Molecular Background of 18F-2-deoxy-D- glucose (FDG) Uptake in the Ischemic Heart.- 18 Imaging Studies in Substance Abuse.- 19 Imaging of Cerebral Metabolism in Huntington’s Disease.- 20 Monoamine Oxidase: Radiotracer Development and Human Studies.- 21 Amino Acid Transport Studies in Brain Tumors.- 22 Lung.- 23 Functional Genomics and the Liver.- 24 Molecular Gastrointestinal Scintigraphy.- 25 The Kidney and Genital System.- 26 Biomolecular Magnification Imaging of Musculoskeletal Diseases.- IV Tumors.- 27 Molecular Imaging in Oncology.- 28 Nuclear (PET/SPECT) Imaging of Gene Expression: Methods and Applications.- 29 Development of DNA-based Radiopharma- ceuticals Carrying Auger-Electron Emitters for Anti-gene Radiotherapy.- V Special Topics.- 30 The Role of Nuclear Medicine in Relation to Alternative Modalities.- 31 MR Contrast Agents for Molecular and Cellular Imaging.- 32Magnetic and Optical Molecular Imaging. Live Cell and Tissue Fluorescence: Imaging Techniques and Methods.- 33 Biological Effects of Low Doses of Ionizing Radiation: Damage versus Protection.

Über Autor(innen)

Over six hundred fifty scientific publications, especially on cell biology, molecular nuclear medicine for in vivo analysis of biochemical reactions, cell responses to low doses of ionizing radiation and to strong static magnetic fields in single- and multi- cellular systems. - Member of numerous national and international advisory groups, committees, boards. Member, Northrhine-Westfalian Academy of Sciences, Germany. Vice-president, Committee for the Annual Meetings of Nobel Prize Winners in Lindau, Germany. Numerous scientific awards and prices.