Ferrer / Thurman Liquid Chromatography Time-of-Flight Mass Spectrometry

Principles, Tools, and Applications for Accurate Mass Analysis
1. Auflage 2009
ISBN: 978-0-470-42995-2
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 280 Seiten, E-Book

Reihe: Chemical Analysis: A Series of Monographs on Analytical Chemistry and Its Applications

Time of flight mass spectrometry identifies the elements of acompound by subjecting a sample of ions to a strong electricalfield. Illuminating emerging analytical techniques inhigh-resolution mass spectrometry, Liquid ChromatographyTime-of-Flight Mass Spectrometry shows readers how to analyzeunknown and emerging contaminants--such as antibiotics,steroids, analgesics--using advanced mass spectrometrytechniques. The text combines theoretical discussion with concreteexamples, making it suitable for analytical chemists, environmentalchemists, organic chemists, medicinal chemists, university researchchemists, and graduate and post-doctorate students.

Autoren/Hrsg.

Ferrer, Imma

Thurman, E. M.

Inhaltsverzeichnis

Part I: Principles and Theoretical Aspects of Accurate Mass.
Chapter 1: Accurate Mass Measurements with Orthogonal Axis Timeof Flight Mass Spectrometry (John C. Fjeldsted).
Chapter 2: The Mass Defect, Isotope Clusters, and Accurate Massfor Elemental Determination (E. Michael Thurman and ImmaFerrer).
Part II: Tools for Unknown Identification using AccurateMass.
Chapter 3: Ion Compostions Determined with Increasing Simplicity(Andrew H. Grange and G. Wayne Sovocool).
Chapter 4: Use and Existence of Accurate Mass Databases andElemental Composition Tools for Target and Non-Target Analyses(Imma Ferrer and E. Michael Thurman).
Chapter 5: Use of UPLC-(Q)-TOF-MS for Rapid Screening of OrganicMicropollutants in Water (Felix Hernandez, Juan V. Sancho and MariaIbanez).
Chapter 6: The Use of Accurate Mass, Isotope Ratios and MS/MSfor the Analysis of PPCPs in Water (Michael C. Zumwalt).
Part III: Applications of LC/TOF-MS for the identification ofsmall molecules.
Chapter 7: Applications of LC/TOF-MS in the Environmental Field:When Did it Start and Where is it Going? (Imma Ferrer and E.Michael Thurman).
Chapter 8: Liquid Chromatography and Ambient IonizationTime-of-Flight Mass Spectrometry for the Analysis of Genuine andCounterfeit Pharmaceuticals (Facundo M. Fern ndez, Christina Y.Hampton, Leonard Nyadong, Arti Navare, Mark Kwasnik).
Chapter 9: Quantitative Analysis of Veterinary Drug Residues bySub 2 ?m Particulate High-Performance Liquid Chromatography Columnsand Time-of-Flight Mass Spectrometry (UPLC-TOF)(AntonKaufmann).
Chapter 10: Industrial Applications of Liquid ChromatographyTime-of-Flight Mass Spectrometry (Jeffrey R. Gilbert, Jesse L.Balcer, Scott A. Young, Dan A. Markham, Dennis O. Duebelbeis, andPaul Lewer).
Chapter 11: Comprehensive Toxicological and Forensic DrugScreening by LC/TOF-MS (Ilkka Ojanper", Anna Pelander andSuvi Ojanper).
12. Chapter 12: Application of UPLC/TOF-MS for Residue Analysisof Veterinary Drugs and Growth Promoting Agents in Products ofAnimal Origin (Alida(Linda) A.M. Stolker).
Chapter 13: Accurate Mass Measurements with a ReflectronTime-of-Flight Mass Spectrometer and the Direct Analysis in RealTime (DART) Interface for the Identification of Unknown CompoundsBelow Masses of 500 Da(O. David Sparkman, Patrick R. Jones, MatthewCurtis).
Chapter 14: Comparison of LC/TOF-MS and LC/MS-MS for theAnalysis of 100 Pesticides in Food: Finding the "Crossover Point"(E. Michael Thurman, Imma Ferrer, Paul A. Zavitsanos and Jerry A.Zweigenbaum).

Über Autor(innen)

Imma Ferrer, PHD, has twelve years of hands-on experience in iontrap, triple quadrupole, and time-of-flight mass spectrometry ofsmall molecules as applied to environmental and pharmaceuticalchemistry. She is currently a Professional Research Associate ofthe Center for Environmental Mass Spectrometry at the University ofColorado in Boulder, Colorado. She is the author of the book LiquidChromatography/Mass Spectrometry, MS/MS and Time-of-Flight MS:Analysis of Emerging Contaminants. She is also the author ofnumerous highly cited papers on the analysis of pesticides andpharmaceuticals by liquid chromatography mass spectrometry.
E. Michael Thurman, PHD, is a highly cited scientist inenvironmental chemistry and an Emeritus Scientist with the U.S.Geological Survey. He is currently Director of the Center forEnvironmental Mass Spectrometry at the University of Colorado, inBoulder, Colorado. His bibliography consists of more than 200publications in environmental chemistry, including more than 100journal articles, twenty proceedings and chapters, and eighty U.S.Geological Survey publications. Dr. Thurman has published fivebooks dedicated to the chemical analysis of pesticides and naturalproducts, sample preparation, and mass spectrometry.