Friedmann Advances in Genetics

1. Auflage 2009
ISBN: 978-0-08-088876-7
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, Band Volume 66, 358 Seiten

Reihe: Advances in Genetics

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area
Presents up-to-date research from leaders in the field
Praise for Advances in Genetics:
'Outstanding both in variety and in the quality of its contributions.'--NATURE
'Can be highly recommended to geneticists, and biologists in general...will prove to be of high importance for the development of the science of genetics.'--SCIENCE

Autoren/Hrsg.

Friedmann, Theodore

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Genetics;4
3;Copyright Page;5
4;Contents;6
5;Contributors;8
6;Chapter 1: The Molecular Links Between TDP-43 Dysfunction and Neurodegeneration;10
6.1;I. Introduction;11
6.2;II. Main Text;14
6.2.1;A. Aggregation/nuclear localization;14
6.2.2;B. Degradation;18
6.2.3;C. Phosphorylation;20
6.2.4;D. Ubiquitination;21
6.2.5;E. Mutations;22
6.3;III. Early Lessons From Animal Models;26
6.4;IV. Gain- Versus Loss-of-Function Scenarios;30
6.5;V. Conclusions;34
6.6;Acknowledgments;36
6.7;References;36
7;Chapter 2: Resources and Strategies to Integrate the Study of Ethical, Legal, and Social Implications of Genetics into the Undergraduate Curriculum;44
7.1;I. Introduction;45
7.2;II. Resources;46
7.2.1;A. Eugenics;46
7.2.2;B. Human ancestry and evolution;48
7.2.3;C. Genetic identification: Forensics;49
7.2.4;D. Genetic testing: Simple inherited diseases;51
7.2.5;E. Genetic testing and counseling;52
7.2.6;F. Genetic testing: A simulation;54
7.2.7;G. Gene therapy and genetic enhancement;56
7.2.8;H. Careful communication;58
7.2.9;I. Analysis of relevant fiction and media;59
7.3;III. Strategies;61
7.3.1;A. Integration of ELSI issues into nonmajors courses;61
7.3.2;B. Integration of ELSI issues into genetics courses for bioscience majors;62
7.4;IV. Concluding Remarks;64
7.5;Acknowledgments;64
7.6;References;64
8;Chapter 3: Synthetic Genetic Interactions: Allele Dependence, Uses, and Conservation;70
8.1;I. Genetic Enhancement;71
8.1.1;A. Background;71
8.1.2;B. Definition;72
8.2;II. Expected Underlying Functional Relationships;74
8.2.1;A. Interactions between null alleles;74
8.2.2;B. Interactions between hypomorphic alleles;76
8.2.3;C. Interactions between hypomorphic and null alleles;77
8.3;III. Systematic Discovery of Genetic Enhancements;78
8.3.1;A. Budding yeast Saccharomyces cerevisiae;78
8.3.1.1;1. SGA analysis;78
8.3.1.2;2. dSLAM;78
8.3.1.3;3. How the methods compare;79
8.3.2;B. Fission yeast Schizosaccharomyces pombe;79
8.3.3;C. Escherichia coli;79
8.3.4;D. Caenorhabditis elegans;80
8.4;IV. Network Characteristics;80
8.4.1;A. Overall network architecture;80
8.4.2;B. Functional basis for the observed interactions;80
8.4.2.1;1. Null-null interactions;80
8.4.2.2;2. Hypomorphic-hypomorphic interactions;81
8.4.2.3;3. Hypomorphic-null interactions;82
8.4.2.4;4. Directly comparing hypomorphic-null and null-null subnetworks;83
8.5;V. Extracting Functional Relationships from Global Networks;85
8.6;VI. Conservation;87
8.7;VII. Conclusions;89
8.8;Acknowledgments;90
8.9;References;90
9;Index;94