From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

Erscheinungsjahr 2020
ISBN: 978-0-12-820187-9
Verlag: William Andrew Publishing

Buch, Englisch, 328 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 660 g

From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors, Volume 88, the latest release in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this updated edition include Targeting muscarinic M1 receptor in neurodegeneration, Photo-switchable allosteric ligands, Computational approaches for the design of mGlu receptor allosteric modulators, Allosteric modulation of GLP-1 receptor in metabolic disorders, Group II mGluR roles in the nervous system and their roles in addiction, RAMPs as allosteric modulators of Class B GPCRs, Structure-based discovery and development of mGlu5 NAMs, and much more.

Zielgruppe

<p>investigators in neuroscience, pharmacology, neurology, psychiatry, medicine. </p>

Autoren/Hrsg.

Weitere Mitwirkende

Langmead, Christopher J.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

- The computational modeling of allosteric modulation of metabotropic glutamate receptors

Laura Pérez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary Tresadern

- Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators

Kirstie A. Bennett, John A. Christopher and Benjamin G. Tehan

- The function and allosteric control of the human sweet taste receptor

Guy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole Servant

- The different aspects of the GABAB receptor allosteric modulation

Julie Kniazeff

- RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors

Augen A. Pioszak and Debbie L. Hay

- Strategies and considerations of G-protein-coupled receptor photopharmacology

Alice E. Berizzi and Cyril Goudet

- Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacology

Francis S. Willard, Joseph D. Ho and Kyle W. Sloop

- Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations

Kari A. Johnson and David M. Lovinger

- Allosteric modulation of muscarinic receptors in alcohol and substance use disorders

Leigh C. Walker and Andrew J. Lawrence

- M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?

Miriam Scarpa, Sarah Hesse and Sophie J. Bradley

Über Autor(innen)

Langmead, Christopher J.
Christopher Langmead is at Monash University, Vic, Australia