Fuchs Handbook of Reagents for Organic Synthesis, Reagents for Silicon-Mediated Organic Synthesis

1. Auflage 2013
ISBN: 978-1-118-63613-8
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 816 Seiten, E-Book

Reihe: Handbook of Reagents for Organic Synthesis

Over the last three decades the importance of organosiliconchemistry has greatly increased because it has opened a number ofnew synthetic strategies. Silicon reagents are usually low-cost,versatile and allow a wide range of reactions. This is the firstHandbook to compile essential Silicon containing reagents and makesuse of the leading reagent database e-EROS. Another hotvolume in the series Handbooks of Reagents for OrganicSynthesis, this is a must-have resource for all syntheticchemists working in drug development and medicinal chemistry.
For the selection the Editor focussed on three key syntheticapproaches with the greatest impact:
1. Use of silicon as a 'temporary tether' by unifying a reactivepair of functional groups and taking advantage of theirtemplate-biased intramolecular cyclization.
2. The specific use of the silane functionality as a heterot-butyl group, often colloquially referred to as the use ofsilicon as a 'fat proton'.
3. The use of the Brook rearrangement as an 'anion relaystratagem'.
A new feature in this Handbook is the reagent finder, analphabetically organized lookup table arranged by organicfunctionality and specific structure of the silicon atom to whichit is bound.

Autoren/Hrsg.

Fuchs, Philip L.