Fungal and Protozoan Carbonic Anhydrases

Erscheinungsjahr 2025
ISBN: 978-0-443-31394-3
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

Fungal and Protozoan Carbonic Anhydrases, Volume 57 in The Enzymes series, explores recent advancements in the study of fungal and protozoan carbonic anhydrases (CAs). This volume presents a comprehensive collection of chapters covering various aspects of these enzymes, including an overview of fungal and protozoan CAs (genetics, molecular biology, and phylogenetics), the structure and function of fungal ?-carbonic anhydrases, and an in-depth look at ?-carbonic anhydrases in Saccharomyces cerevisiae, Candida spp., and Cryptococcus neoformans. Additional chapters delve into the Malassezia spp. and Sordaria macrospora CAs, as well as protozoan CAs from Plasmodium falciparum, Trypanosoma cruzi, Leishmania spp., Toxoplasma gondii, and Entamoeba histolytica. The volume also addresses the challenges in developing selective fungal and protozoal CA inhibitors as anti-infective agents, providing insights into their potential biomedical applications.

Autoren/Hrsg.

Weitere Mitwirkende

Supuran, Claudiu T.

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Biowissenschaften
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1. Overview on fungal and protozoan carbonic anhydrases
2. Fungal ?- carbonic anhydrases
3. Saccharomyces cerevesiae, Candida spp. and Cryptococcus neoformans ?- carbonic anhydrases
4. Malassezia spp. carbonic anhydrases
5. Sordaria macrospora carbonic anhydrases
6. Plasmodium falciparum ?-CA
7. Trypanosoma cruzi and Leishmania spp. CAs
8. Toxoplasma gondii, Babesia and other protozoan CAs
9. Trichomonas vaginalis CA
10. Entamoeba histolytica CA
11. Challenges for developing selective fungal/protozoal CA inhibitors as antiinfectives

Über Autor(innen)

Supuran, Claudiu T.
Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields.