Introduction to Biological and Small Molecule Drug Research and Development

Theory and Case Studies
Erscheinungsjahr 2013
ISBN: 978-0-12-397176-0
Verlag: Elsevier Science

Buch, Englisch, 472 Seiten, Format (B × H): 195 mm x 241 mm, Gewicht: 1117 g

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

Zielgruppe

undergraduate / postgraduate scientists who wish to understand or who are working on drug discovery or starting their careers in the biotech, medicinal chemistry, pharmaceutical industry and corporates

Autoren/Hrsg.

Ganellin, C Robin

Jefferis, Roy

Roberts, Stanley M

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie

Inhaltsverzeichnis

1. 'Introduction to Enzymes, Receptors and Small Molecule Drugs'

2. Proteins: Structure and Function

3. The Drug Discovery Process - from Target Selection to Candidate

4. Introduction to Biopharmaceuticals

5. Similarities and Differences in the Discovery, Development and Use of Biopharmaceuticals versus Small Molecule Drugs

6. 'Approaching the Same.Treatment of Diabetes
7. The Structure and Business of Bio/pharmaceutical Companies including the Management of Risks and Resources

8. Gefitinib

9. Herceptin/T-DM1

10. Erythropoietin (Epogen/Eprex/NeoRecormon)

11. Lysosomal Storage diseases

12. Steroids for HRT
13. Anti-HIV protease inhibitor Darunavir

14. Anti-TNF Agents Remicade/Humira/Enbrel/Cimzia
15. The Cholesterol Lowering Drug - Ezetimibe