Intratumor diversity and clonal evolution in cancer

Erscheinungsjahr 2011
ISBN: 978-0-12-387688-1
Verlag: Academic Press

Buch, Englisch, 368 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 820 g

This specialized volume of Advances in Cancer research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors.


Unique subject matter: there are relatively few previous publications covering this complex topic, even though it has been a matter of much speculation ever since cancers were first studied under the microscope more than a century ago. This volume is an attempt to up-date the reader on novel findings as well as giving a historical perspective to the field. It thereby offers en excellent starting point for young scientists entering this field of research.
Contributors: many of the contributors are renowned cancer researchers with long term experience. In order to bring in new ideas to the field these experienced authors have been blended with young bright minds who might provide novel starting points for solving old problems.
Technical aspects: some chapters will be focused on specific techniques to address intratumor diversity and will therefore be helpful for colleagues wanting to broaden their technical expertise.

Zielgruppe

Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.</p>

Autoren/Hrsg.

Gisselsson, David

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

Introduction Role of telomere dysfunction in genetic intratumour diversity How mitotic errors contribute to karyotypic diversity in cancer Nuclear Remodelling as a Mechanism for Genomic Instability in Cancer Cytogenetic Analysis of Tumor Clonality Genotyping techniques to address diversity in tumors Prostate Cancer as a Model System for Genetic Diversity in Tumours Evolutionary mechanisms and diversity in cancer Cancer stem cells in tumor heterogeneity Cancer: Beyond Speciation