Regenerative Nephrology

Erscheinungsjahr 2016
ISBN: 978-0-12-810196-4
Verlag: William Andrew Publishing

Buch, Englisch, 442 Seiten, Format (B × H): 216 mm x 276 mm, Gewicht: 1270 g

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts.

Zielgruppe

<p>Medical and pharmaceutical researchers in nephrology and related renal diseases; fellows and academic clinicians in nephrology; biomedical researchers who work with stem cells.</p>

Autoren/Hrsg.

Goligorsky, Michael S.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Nephrologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

PHYLOGENY AND ONTOGENY OF TISSUE REGENERATION 1. Glomerulogenesis and de novo nephrogenesis in medaka fish - evolutionary approach Yuko Wakamatsu and Hisashi Hashimoto 2. Renal Organogenesis: Growing a replacement kidney in situ from transplanted renal primordia Marc R. Hammerman 3. Use of Genetic Mouse Models to study Kidney Regeneration Akio Kobayashi and Jeremy S. Duffield

MEDIATORS OF REGENERATION 4. Endogenous Anti-Inflammatory and Pro-Resolving Lipid Mediators in Renal Disease Charles N. Serhan and Catherine Godson 5. Tissue protection and regeneration aided by erythropoietin and erythropoietin-derived peptides Danilo Fliser 6. Mast cells in kidney regeneration Eric Daugas, Walid Beghdadi and Ulrich Blank 7. Role of macrophages in renal injury, repair and regeneration Vincent Lee, Qi Cao, Yiping Wang and David C.H. Harris 8. T-cells contribution to regenerative processes Hamid Rabb

STEM CELLS IN REGENERATIVE PROCESSES 9. MSC and reparative processes Benjamin D. Humphreys and John V. Bonventre 10. Stem cells in regenerative processes: Endothelial progenitor cells and the kidney Matthieu Monge, Anton J. van Zonneveld and Ton J. Rabelink 11. The potential of the side population in regenerative nephrology Melissa H. Little and G. A. Challen 12. Very small embryonic like stem cells (VSELs) and their potential relevance for kidney homeostasis Dong-Myung Shin, Rui Liu, Janina Ratajczak, Magda Kucia and Mariusz Z. Ratajczak 13. Stem Cells in Regenerative Processes; Induced Pluripotent Stem Cells Kenji Osafune and Shinya Yamanaka 14. Methods of Isolation and Culture of Adult Stem cells Lindolfo da Silva Meirelles and Nance Beyer Nardi

STEM CELLS - FROM THE NICHE TO REPAIR 15. Stem cell niche in the kidney Laura Lasagni, Elena Lazzeri and Paola Romagnani 16. Creation of artificial niches Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff and Michael S. Goligorsky 17. Imaging of transplanted and native stem cells Xiang-Yang Zhu, Martin Rodriguez-Porcel and Lilach O. Lerman

CAUSES OF REGENERATIVE FAILURE 16. Stem cell injury and premature senescence Michael S. Goligorsky 17. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway Nica M. Borradaile, Alanna Watson, and J. Geoffrey Pickering 18. Bone marrow-mesenchymal stem cells in organ repair and strategies to optimize their efficacy Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi and Marina Morigi

EMERGING CLINICAL ASPECTS OF STEM CELL THERAPY 19. Treatment of Acute Kidney Injury with allogeneic Mesenchymal Stem Cells: Preclinical and initial Clinical Data Florian E. Tögel and Christof Westenfelder 20. Clinical trials in Renal Regenerative Medicine Maarten B. Rookmaaker, Jaap A. Joles and Marianne C. Verhaar 21. Potential risks of stem cell therapies Uta Kunter and Jürgen Floege 22. Tissue engineering in urology Anthony Atala 23. Ethical issues in SC therapy Donald W. Landry 24. Stem Cell Banking Vicente Mirabet and Pilar Solves

Über Autor(innen)

Goligorsky, Michael S.
Michael S. Goligorsky, MD. PhD, holds the Alvin I. Goodman Chair in Nephrology, and is Professor of Medicine, Pharmacology and Physiology and Director of Renal Research Institute at the New York Medical College, Touro University. Dr. Goligorsky serves as an Associate Editor for Am J Pathology and is a member of the Association of American Physicians (elected 2002). His research interests include: the mechanisms of endothelial dysfunction as a harbinger of diabetic, and hypertensive vascular damage; stress-induced premature senescence of endothelial cells and the role of lysosomal dysfunction in this process; mechanisms of functional incompetence of endothelial cells in chronic kidney disease; and mechanisms of alarm signaling by an ischemic kidney.