Gpcr Signaling in Cancer

Erscheinungsjahr 2020
ISBN: 978-0-12-820230-2
Verlag: ACADEMIC PR INC

Buch, Englisch, Band 145, 164 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 410 g

Reihe: Advances in Cancer Research

GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more.

G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.

Zielgruppe

<p>Primary researchers and clinicians involved in molecular oncology research and cancer therapeutics</p>

Autoren/Hrsg.

Weitere Mitwirkende

Shukla, Arun K.

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Virologie
• Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

1. HERs Transregulation in Cancer Progression: From Discovery to 2020 and Beyond Rakesh Kumar 2. RTKs in Cancer Biology Paul Fisher 3. Advances in EGFR Biochemistry and Biology Yosef Yarden 4. Mouse Models of RTKs/HERs: Lessons and Implications to Biology and Therapy William Joseph Muller 5. MET Receptor in Oncology: From Biomarker to Therapeutic Target Ravi Salgia 6. RTKs in Pathobiology of Head & Neck Cancer Radhakrishna Pillai 7. HER2 or Nuclear HER/RTK in Cancer Mien-Chie Hung 8. FLT3 in Hematopietic Malignancies: From Pathobiology to Therapeutics Premkumar Reddy 9. Advances in IGF1R Biology and -directed Cancer Therapeutics Douglas Yee 10. Advances in Bcr-Abl in Cancer Therapy and Biology Nandini Verma 11. EphRs in Cancer Development and Progression Renata Pasqualini 12. RTK-directed Clinical Advances: Trials and Treatments Masakazu Toi

Über Autor(innen)

Shukla, Arun K.
Dr. Arun K. Shukla is a world leader in the field of GPCR biology and he is currently a Professor in the Department of Biological Sciences and Bioengineering at the Institute of Technology, Kanpur in India. Dr. Shukla's research program is focused on understanding the structure, function and regulation of G protein-coupled receptors with a long-term of designing novel therapeutics with minimized side-effects.