Gross / Chen / Pramanik Protein and Peptide Mass Spectrometry in Drug Discovery

1. Auflage 2011
ISBN: 978-1-118-11654-8
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 484 Seiten, E-Book

The book that highlights mass spectrometry and its applicationin characterizing proteins and peptides in drug discovery
An instrumental analytical method for quantifying the mass andcharacterization of various samples from small molecules to largeproteins, mass spectrometry (MS) has become one of the most widelyused techniques for studying proteins and peptides over the lastdecade. Bringing together the work of experts in academia andindustry, Protein and Peptide Mass Spectrometry in DrugDiscovery highlights current analytical approaches, industrypractices, and modern strategies for the characterization of bothpeptides and proteins in drug discovery.
Illustrating the critical role MS technology plays incharacterizing target proteins and protein products, the methodsused, ion mobility, and the use of microwave radiation to speedproteolysis, the book also covers important emerging applicationsfor neuroproteomics and antigenic peptides. Placing an emphasis onthe pharmaceutical industry, the book stresses practice andapplications, presenting real-world examples covering the mostrecent advances in mass spectrometry, and providing an invaluableresource for pharmaceutical scientists in industry and academia,analytical and bioanalytical chemists, and researchers in proteinscience and proteomics.

Autoren/Hrsg.

Gross, Michael L.

Chen, Guodong

Pramanik, Birendra

Über Autor(innen)

Michael L. Gross, PhD, is a Professor in the Departments ofChemistry, Medicine, and Immunology at Washington University in St.Louis. He is also Principal Investigator at the National Institutesof Health (NIH) Research Resource in Mass Spectrometry.
Guodong Chen, PhD, is Principal Scientist inBioanalytical and Discovery Analytical Sciences at Bristol-MyersSquibb in Princeton, New Jersey. He heads a mass spectrometry groupin support of drug discovery as well as development programs insmall molecule pharmaceuticals and biologics.
Birendra N. Pramanik, PhD, was a Distinguished Fellow atSchering-Plough Research Institute (SPRI), where he directed thespectroscopy, mass spectrometry, and NMR programs.