Hall Advances in Genetics

1. Auflage 2011
ISBN: 978-0-08-046331-5
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 56, 224 Seiten, Web PDF

Reihe: Advances in Genetics

The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Articles covered in this volume include Biological Activity and Biotechnological Aspects of Peptide Nucleic Acid (PNA); Changing Images of the Gene; Historical and Modern Genetics of Plant Graft Hybridization; Step into the Groove: Engineered Transcription Factors as Modulators of Gene Expression; Step Out of the Groove: Epigenetic Gene Control Systems and Engineered Transcription Factors.

Autoren/Hrsg.

Hall, Jeffrey C.

Inhaltsverzeichnis

1;Cover Page;1
2;Contents;6
3;Contributors;8
4;Chapter 1: Biological Activity and Biotechnological Aspects of Peptide Nucleic Acid;9
4.1;I. Introduction;10
4.2;II. PNA: Chemistry and Structure;12
4.3;III. Biological Activity;21
4.4;IV. Biotechnological Aspects of PNA;37
4.5;V. Concluding Remarks;46
4.6;Acknowledgments;46
4.7;References;46
5;Chapter 2: Changing Images of the Gene;61
5.1;I. Introduction;62
5.2;II. The Hypothetical Gene;63
5.3;III. Physical Concepts of the Gene;65
5.4;IV. Chemical Nature of the Gene;67
5.5;V. The Genetic Code;71
5.6;VI. Structure of the Gene;72
5.7;VII. Molecular Units of the Gene;76
5.8;VIII. Higher Orders of Genes;78
5.9;IX. Gene Number and Gene Size;81
5.10;X. Genes in the Cytoplasm;83
5.11;XI. Epigenetics;86
5.12;XII. Prions;91
5.13;XIII. Conclusions and Outlook;94
5.14;XIV. Epilog;95
5.15;Acknowledgments;96
5.16;References;96
6;Chapter 3: Historical and Modern Genetics of Plant Graft Hybridization;109
6.1;I. Introduction;110
6.2;II. Historical Background;111
6.3;III. The Existence of Graft Hybrids;115
6.4;IV. Methods of Graft Hybridization;122
6.5;V. Characteristics of Graft Hybridization;123
6.6;VI. Mechanisms Underlying Graft Hybridization;124
6.7;VII. Significance of Graft Hybridization;128
6.8;VIII. Conclusions;132
6.9;Acknowledgments;133
6.10;References;133
7;Chapter 4: Step into the Groove: Engineered Transcription Factors as Modulators of Gene Expression;139
7.1;I. Introduction;140
7.2;II. Transcriptional Therapy;142
7.3;III. Engineered Zinc-Finger-Based Transcription Factors (ZF-TFs) and the Influence of Nucleosomes;156
7.4;IV. Concluding Remarks and Future Perspectives;163
7.5;Acknowledgments;164
7.6;References;164
8;Chapter 5: Step out of the Groove: Epigenetic Gene Control Systems and Engineered Transcription Factors;171
8.1;I. Influence of Epigenetic Mechanisms on Gene Expression;172
8.2;II. How Do ZF-TFs Modulate Epigenetic Gene Regulation?;190
8.3;III. Epigenetic Aspects to Consider for ZF-TF Approaches;199
8.4;Acknowledgments;204
8.5;References;204
9;Index;213