Hall Advances in Genetics

1. Auflage 2005
ISBN: 978-0-08-052233-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 55, 200 Seiten, Web PDF

Reihe: Advances in Genetics

The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

Autoren/Hrsg.

Hall, Jeffrey C.

Inhaltsverzeichnis

1;Cover;1
2;Title Page;4
3;Copyright Page;5
4;Contents;6
5;Contributors;10
6;Chapter 1. Site-Specific DNA Recombinases as Instruments for Genomic Surgery;12
6.1;I. Introduction;13
6.2;II. Inadequacy of Current Methods;13
6.3;III. Site-Specific Recombination;15
6.4;IV. Mechanisms of Site-Specific Recombination;16
6.5;V. Transposition;19
6.6;VI. Applied Site-Specific Recombination and Transposition Systems;20
6.7;VII. Changing Recombination Site Specificity;20
6.8;VIII. Mutagenesis-Selection Strategies;21
6.9;IX. Structure-Based Strategies. Z-Resolvases;23
6.10;X. Targeting Transposition to Specific Sequences;26
6.11;XI. General Considerations in Applications of Site-Specific Recombinases and Transposases;27
6.12;XII. Prospects and Conclusions ;29
6.13;References;30
7;Chapter 2. Human Clinical Trials of Plasmid DNA Vaccines;36
7.1;I. Background;37
7.2;II. Development of DNA Vaccines for Clinical Trials;39
7.3;III. Human Clinical Trials;42
7.4;IV. Limitations of DNA Vaccine Potency;44
7.5;V. Prospects and Conclusion;46
7.6;References;46
8;Chapter 3. Genetic and Environmental Influences on Antisocial Behaviors. Evidence from;52
8.1;I. Appraising the Quantitative Behavioral–Genetic Evidence Base;55
8.2;II. Estimating the Relative Influences of Genes and Environments;69
8.3;III. Do the Omnibus Estimates of Genetic and Environmental Influences Always Apply, or do These Influences Vary Under Different Conditions?;77
8.4;IV. Testing Developmental Theory of Antisocial Behavior;82
8.5;V. Testing Hypotheses About Environmental Causation;85
8.6;VI. Testing the Hypothesis of Interaction Between Genes and Environments;91
8.7;VII. The Way Forward;99
8.8;References;102
9;Chapter 4. Genetics of Graviperception in Animals;116
9.1;I. Introduction;117
9.2;II. Vertebrate Genetic Models;118
9.3;III. The Arthropod Genetic Model;131
9.4;IV. The Nematode Model System;146
9.5;V. Conclusion;148
9.6;References;149
10;Chapter 5. Retroviral DNA Integration„Mechanism and Consequences;158
10.1;I. Introduction;159
10.2;II. Retroviral Life Cycle;159
10.3;III. Mechanism of Integration;160
10.4;IV. Integrase Structure;164
10.5;V. Composition of Integrase Complexes In Vivo;170
10.6;VI. Retroviral Integration Targeting;173
10.7;VII. Consequences of Integration into Host Chromosomes;177
10.8;VIII. Conclusions;180
10.9;References;181
11;Index;194
12;Color Plate Section;198