Han / Kaplowitz Mitochondria in Liver Disease

Erscheinungsjahr 2015
ISBN: 978-1-4822-3698-9
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 511 Seiten

Reihe: Oxidative Stress and Disease

This book gathers the most current research regarding the role of mitochondria, often referred to as the "powerhouse of the cell" due to its role in metabolism. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcohol fatty liver disease. Novel topics such as regulation of mitochondrial respiration by hydrogen sulfide and regulation of mitochondrial fusion-fission provide a comprehensive overview of mitochondria and its central role in mediating liver diseases.

Autoren/Hrsg.

Han, Derick

Kaplowitz, Neil

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Endokrinologie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Gastroentereologie, Proktologie

Inhaltsverzeichnis

Overview of Mitochondria. Mitochondrial Fusion-Fission Dynamics: Role of the Endoplasmic Reticulum (ER). Topology of Reactive Oxygen Species Generation by Mitochondria. Regulation of Mitochondrial Bioenergetics by Acetylation and Sirtuins. Mitochondria-Associated ER Membranes (MAMs) in Cell Signaling. Autophagy and Oxidative Stress. Regulation of Mitochondrial Respiration and Reactive Oxygen Species Generation by Nitric Oxide. Regulation of Mitochondrial Respiration by Hydrogen Sulfide. Interconnection of Energy-Transducing Capacity and Redox Status in Mitochondria: The Energy-Redox Axis in Mitochondria. Role of Cytochrome C in Mitochondrial Bioenergetics and Cell Signaling. Role in Mitochondria in Liver Diseases. Role of Autophagy and Mitophagy in Liver Diseases. Cytochrome P450, Oxidative Stress, and Alcoholic Liver Disease. Mitochondrial Dynamics in Alcoholic Liver Disease: Biogenesis, Remodeling, and Functional Alterations. Role of Oxidative Stress and JNK in Liver Lipotoxicity. Hepatitis C and Mitochondrial Dysfunction in the Liver. Protective Effects of Peroxiredoxins Against Liver Injury. Changes in the Mitochondrial Proteome in Fatty Liver Disease. Mitochondrial DNA Alterations in Liver Diseases. Nicotinamide Adenine Dinucleotide Phosphate Oxidase in Liver Fibrosis. Central Role of Mitochondria in Drug-Induced Liver Injury. Mitochondria Targeted Antioxidants for Treatment of Liver Diseases. MtDNA as Biomarkers of Drug-Induced Liver Injury. Damaged-Associated Molecular Pattern Molecules (DAMPs) in Liver Disease.