Modern Methods of Drug Discovery

Softcover Nachdruck of the original 1. Auflage 2003
ISBN: 978-3-0348-9397-8
Verlag: Birkhäuser Basel

Buch, Englisch, Band 93, 292 Seiten, Paperback, Format (B × H): 155 mm x 235 mm, Gewicht: 470 g

Reihe: Experientia Supplementum

This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It comprehensively covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds-, and NMR-based-screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the thirteen chapters reviews the theory, background and application of a key technology in drug discovery and is complemented by an extensive list of references to the original literature.

This concise source of information will be useful to workers in the pharmaceutical industry as well as researchers and students in the fields of medicinal, pharmaceutical and computational chemistry, bioinformatics, biochemistry, molecular biology and pharmacology.

Zielgruppe

Research

Autoren/Hrsg.

Hilgenfeld, Rolf

Hillisch, Alexander

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie
• Naturwissenschaften Chemie Organische Chemie
• Naturwissenschaften Chemie Analytische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

1 Modern methods of drug discovery: An introduction.- 2 Proteomics.- 3 Bioinformatics.- 4 High-throughput screening technologies.- 5 Natural products for lead identification: Nature is a valuable resource for providing tools.- 6 Combinatorial chemistry: Mixture-based combinatorial libraries of acyclic and heterocyclic compounds from amino acids and short peptides.- 7 Computational approaches towards the quantification of molecular diversity and design of compound libraries.- 8 The role of protein 3D-structures in the drug discovery process.- 9 NMR-based screening methods for lead discovery.- 10 Structure-based design of combinatorial libraries.- 11 3D QSAR in modern drug design.- 12 Physicochemical concepts in drug design.- 13 Computer-aided prediction of drug toxicity and metabolism.