Hime / Abud Transcriptional and Translational Regulation of Stem Cells

2013
ISBN: 978-94-007-6621-1
Verlag: Springer Netherland
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 371 Seiten, eBook

Reihe: Biomedical and Life Sciences

This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Zielgruppe

Research

Autoren/Hrsg.

Hime, Gary

Abud, Helen

Inhaltsverzeichnis

1. The stem cell state; Gary R. Hime and Helen E. Abud2. Induction of pluripotency; Corey Heffernan, Jun Liu, Huseyin Sumer, Luis F. Malaver-Ortega, Rajneesh Verma, Edmund Carvalho and Paul J. VermaModel stem cell systems(A) Invertebrate3. Germline stem cells and their regulation in the nematode Caenorhabditis elegans; Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter and Judith Kimble4. Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny; Helen White-Cooper and Simona Caporilli5. Stem cells in the Drosophila digestive system; Xiankun Zeng, Chhavi Chauhan, and Steven X. Hou6. Mechanisms of Asymmetric Progenitor Divisions in the Drosophila Central Nervous System; Rita Sousa-Nunes and W. Gregory Somers(B) Vertebrate7. Transcriptional / Translational Regulation of Mammalian Spermatogenic Stem Cells; Cathryn Hogarth8. Transcriptional Regulation and Specification of Neural Stem Cells; Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate and Ann M. Turnley9. Transcriptional Control of Epidermal Stem Cells; Briana Lee and Xing Dai10. Regulation of intestinal stem cells by Wnt and Notch signalling; Katja Horvay and Helen E. Abud 11. Transcriptional regulation of haematopoietic stem cells; Adam C. Wilkinson and Berthold Göttgens12. Regulation of mesenchymal stem cell differentiation; David Cook and Paul GeneverMolecular families implicated in stem cell regulation13. The Musashi family of RNA binding proteins: Master regulators of multiple stem cell populations; Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime and Nicole A. Siddall 14. JAK-STAT signalling in stem cells; Rachel R. Stine and Erika L. Matunis15. Myc in Stem Cell Behaviour: insights from Drosophila; Leonie M. Quinn, Julie Secombe and Gary R. Hime16. The Role of Nuclear Receptors in Embryonic Stem Cells; Qin Wang and Austin J. Cooney17. Epigenetic regulation of stem cells; Anton Wutz18. Regulation of stem cell populations by microRNAs; Julie Mathieu and Hannele Ruohola-Baker19. Myb and the Regulation of stem cells in the Intestine and Brain: A Tale of Two Niches; Jordane Malaterre, Lloyd Pereira and Robert G. RamsayIndex