Buch, Englisch, 300 Seiten, Format (B × H): 216 mm x 279 mm, Gewicht: 816 g
Buch, Englisch, 300 Seiten, Format (B × H): 216 mm x 279 mm, Gewicht: 816 g
ISBN: 978-0-8493-7741-9
Verlag: CRC Press
This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.
Zielgruppe
Neurologists, molecular biologists, cellular biologists, pathologists.
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Overview: The Neuronal Cytoskeleton: Roles in Neuronal Morphogenesis and Organelle Transport, N. HirokawaMolecular Genetics of Kinesin Motors, L.S.B. GoldsteinCharacterization of Human Kinesin Heavy Chain Genes, R. Vale, F. Navone, J. Niclas, and N. Hom-BooherThe Molecular Basis of Fast Axonal Transport, G.S. BloomRegulation of Organella Transport by Phosphorylation of Kinesin and by Decoration of Microtubules with Microtubule-Associated Proteins, R. Sato-Yoshitake, Y. Okada, S. Okabe, T. Umeyama, and N. HirokawaAxonal Homeostasis and the Nature of Regulated Retrograde Organelle Transport, P.J. Hollenbeck and R.S. WeldKinectin: A Kinesin Receptor on Endoplasmic Reticulum, I. Toyoshima and M.P. SheetzNeurogenesis and Cytoskeleton: Expression of the Nestin Intermediate Filament in Neurepithelial Stem Cells, L.B. Zimmerman and R.D.G. McKayMolecular and Developmental Studies of Neuronal Intermediate Filaments, G.Y. Ching, M.P. Kaplan, and R.K.H. LiemGelsolin is Involved in Myelin Formation, J. Tanaka and K. SobueDynamics of the Neuronal Cytoskeleton, S. Okabe and N. HirokawaSites of Microtubule Assembly in Growing, M.M. Black and A. BrownRegulation of Tubulin Organization in the Axon, T. TashiroSteroid Hormone Effect of Neuronal Configuration-In Vivo and In Vitro Studies, M. Kawata, K. Yuri, N. Morita, and M. MorimotoMicrotubule Bundling by Tau Proteins In Vivo, Y. Kanai and N. HirokawaNuclear Tau Proteins: Implications in Alzheimer's Disease and Down Syndrome, R.P. Zinkowski, R.E. Powers, P.A. Loomis, Y. Wang, and L.I. BinderTau Proteins and Alzheimer's Disease, M. GoedertAbnormal Phosphorylation of Tau in the Alzheimer's Disease Brain, M. Hasegawa, M. Morishima, K. Takio, M. Suzuki, A. Watanabe, T. Arai, K. Titani, and Y. IharaCa2+-Dependent Regulation of the Neuronal Cytoskeleton, K. SobueAnnexin VI-Binding Proteins in Brain, M. Inui, T. Watanabe, M. Iga, B.-Y. Chen, and K. SobueIs Dynamin GTPase a Microtubule Associated Motor?, T. Nakata, Y. Noda, K. Maeda, R. Sato-Yoshitake, Y. Okada, R. Takemura, and N. HirokawaCompartmentation of p60c-src Complex in Developing Rat Forebrain Membrane, K. Ozawa, S. Tadokoro, M. Kira, M. Takahashi, O. Takeuchi, and K. SobueIdentifying Novel Synapse Associated Proteins, C.C. Garner, A. Garner, B. Vob, U. Appeltauer, and E.D. Gundelfinger)Subject IndexAuthor Index
