Buch, Englisch, 179 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 1010 g
Buch, Englisch, 179 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 1010 g
Reihe: Progress in Inflammation Research
ISBN: 978-3-7643-6402-1
Verlag: Springer
Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.
Zielgruppe
Professional/practitioner
Autoren/Hrsg.
Fachgebiete
- Naturwissenschaften Biowissenschaften Biowissenschaften Genetik und Genomik (nichtmedizinisch)
- Naturwissenschaften Biowissenschaften Molekularbiologie
- Naturwissenschaften Biowissenschaften Botanik Pflanzenreproduktion, Verbreitung, Genetik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
- Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Allergologie
- Naturwissenschaften Biowissenschaften Tierkunde / Zoologie Tiergenetik, Reproduktion
Weitere Infos & Material
Heredity of allergy and asthma 1.- Genome scans for asthma.- The role of founder populations in mapping complex disease genes: Studies in the South Dakota Hutterites.- Genetic regulation of specific IgE responsiveness.- Genetic variation at the HLA and TCR loci and the development of allergy and asthma.- Chromosome 11q13, FccRI13 and atopic asthma.- Genetic regulation of interleukin-13 production.- The role of interleukin-9 and the interleukin-9 receptor gene candidates in asthma.- Genetics of the nitric oxide synthetic pathway in asthma.- Genetic regulation of leukotriene production and activity.- Genetics of asthma severity.
